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   Articles with "ppgpp" as a keyword



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Significance of accumulation of the alarmone (p)ppGpp in chloroplasts for controlling photosynthesis and metabolite balance during nitrogen starvation in Arabidopsis

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recommendations! Published in 2017 at "Photosynthesis Research"

DOI: 10.1007/s11120-017-0402-y

Abstract: The regulatory nucleotides, guanosine 5′-triphosphate 3′-diphosphate (pppGpp) and guanosine 5′-diphosphate 3′-diphosphate (ppGpp), were originally identified in Escherichia coli, and control a large set of gene expression and enzyme activities. The (p)ppGpp-dependent control of cell activities… read more here.

Keywords: ppgpp; arabidopsis; metabolite balance; balance nitrogen ... See more keywords
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Characterization of genes involved in (p)ppGpp precursor biosynthesis in Erwinia amylovora

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recommendations! Published in 2020 at "Journal of Plant Pathology"

DOI: 10.1007/s42161-020-00583-6

Abstract: Previous studies have shown that the hypersensitive response and pathogenicity (hrp)-type III secretion system (T3SS) is activated by the bacterial alarmone (p)ppGpp, which mediates the stringent response in nutrient starvation conditions in Erwinia amylovora. ATP… read more here.

Keywords: genes involved; erwinia amylovora; biosynthesis; adenine gmp ... See more keywords
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Influence of (p)ppGpp on biofilm regulation in Pseudomonas putida KT2440.

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recommendations! Published in 2017 at "Microbiological research"

DOI: 10.1016/j.micres.2017.07.003

Abstract: The global regulatory molecule (p)ppGpp is synthesized under limited nutrition conditions and involves in many cellular processes in bacteria. (p)ppGpp has been reported to affect biofilm formation in several bacterial species. Here, we found that… read more here.

Keywords: pseudomonas putida; ppgpp; biofilm formation; biofilm ... See more keywords
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(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2019.03.035

Abstract: The stringent response alarmones pppGpp and ppGpp are essential for rapid adaption of bacterial physiology to changes in the environment. In Escherichia coli, the nucleosidase PpnN (YgdH) regulates purine homeostasis by cleaving nucleoside monophosphates and… read more here.

Keywords: ppnn; ppgpp; ppgpp regulates; bacterial nucleosidase ... See more keywords
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Sound the (Smaller) Alarm: The Triphosphate Magic Spot Nucleotide pGpp

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recommendations! Published in 2023 at "Infection and Immunity"

DOI: 10.1128/iai.00432-22

Abstract: It has recently become evident that the bacterial stringent response is regulated by a triphosphate alarmone (pGpp) as well as the canonical tetra- and pentaphosphate alarmones ppGpp and pppGpp [together, (p)ppGpp]. Often dismissed in the… read more here.

Keywords: pgpp; smaller alarm; gdp gtp; alarm triphosphate ... See more keywords
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DksA, ppGpp, and RegAB Regulate Nitrate Respiration in Paracoccus denitrificans

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recommendations! Published in 2023 at "Journal of Bacteriology"

DOI: 10.1128/jb.00027-23

Abstract: Paracoccus denitrificans is a metabolically versatile Gram-negative bacterium that is used as a model for studies of respiratory metabolism. The organism can utilize nitrate as an electron acceptor for anaerobic respiration, reducing it to dinitrogen… read more here.

Keywords: paracoccus denitrificans; expression; regab; respiration ... See more keywords
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The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC

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recommendations! Published in 2019 at "mBio"

DOI: 10.1128/mbio.01330-19

Abstract: To survive bouts of starvation, cells must inhibit DNA replication. In bacteria, starvation triggers production of a signaling molecule called ppGpp (guanosine tetraphosphate) that helps reprogram cellular physiology, including inhibiting new rounds of DNA replication.… read more here.

Keywords: initiation; replication; ppgpp; dna replication ... See more keywords
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The stringent response regulator (p) ppGpp mediates virulence gene expression and survival in Erwinia amylovora

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recommendations! Published in 2020 at "BMC Genomics"

DOI: 10.1186/s12864-020-6699-5

Abstract: The nucleotide second messengers, i.e., guanosine tetraphosphate and pentaphosphate [collectively referred to as (p) ppGpp], trigger the stringent response under nutrient starvation conditions and play an essential role in virulence in the fire blight pathogen… read more here.

Keywords: ppgpp0 mutant; erwinia amylovora; response; stringent response ... See more keywords
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Design of a novel antimicrobial peptide 1018M targeted ppGpp to inhibit MRSA biofilm formation

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recommendations! Published in 2021 at "AMB Express"

DOI: 10.1186/s13568-021-01208-6

Abstract: Methicillin-resistant staphylococcus aureus (MRSA) and its biofilm infection were considered as one of the main international health issues. There are still many challenges for treatment using traditional antibiotics. In this study, a mutant peptide of… read more here.

Keywords: peptide; idr 1018; design novel; ppgpp ... See more keywords
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Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli

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recommendations! Published in 2020 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2020.562804

Abstract: Stringent response mediated by modified guanosine nucleotides is conserved across bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT proteins synthesize the modified nucleotides ppGpp and pppGpp, together referred to… read more here.

Keywords: escherichia coli; stringent response; spot; ppgpp ... See more keywords

Comparison of Anticancer Activities and Biosafety Between Salmonella enterica Serovar Typhimurium ΔppGpp and VNP20009 in a Murine Cancer Model

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recommendations! Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.914575

Abstract: Salmonella Typhimurium defective in guanosine 5′-diphosphate-3′-diphosphate (ppGpp) synthesis (ΔppGpp) is an attenuated strain with good biosafety and excellent anticancer efficacy. It has been widely applied in preclinical studies of anticancer therapy for various types of… read more here.

Keywords: ppgpp vnp20009; salmonella; anticancer; typhimurium ... See more keywords