Metabolic Engineering Strategies Based on Secondary Messengers (p)ppGpp and C-di-GMP To Increase Erythromycin Yield in Saccharopolyspora erythraea.
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DOI: 10.1021/acssynbio.8b00372
Abstract: Secondary messengers (such as (p)ppGpp and c-di-GMP) were proved to play important roles in antibiotic biosynthesis in actinobacteria. In this study, we found that transcription levels of erythromycin-biosynthetic ( ery) genes were upregulated in nutrient… read more here.
Keywords: messengers ppgpp; secondary messengers; ppgpp gmp; ery genes ... See more keywords