Ag(I)/PPh3-catalyzed diastereoselective syntheses of spiro[indole-3,4'-piperidine] derivatives via cycloisomerizations of tryptamine-ynamides.
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DOI: 10.1039/d1cc07298f
Abstract: A Ag(I)/PPh3-catalyzed chelation-controlled cycloisomerization of tryptamine-ynamide was developed to access the spiro[indole-3,4'-piperidine] scaffold in a racemic and diastereoselective manner. The diastereoselective products were achieved by a chiron approach. Density functional theory (DFT) calculations indicated that… read more here.
Keywords: diastereoselective syntheses; catalyzed diastereoselective; indole piperidine; pph3 catalyzed ... See more keywords
PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones
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DOI: 10.1080/00397911.2020.1815784
Abstract: Abstract A method using PPh3/I2-catalyzed three-component Biginelli reaction of aromatic ketone, aromatic aldehyde and urea to synthesize4,6-diarylpyrimidin-2-(1H)-ones is described. Under the experimental conditions, the main reaction products are 4,6-diarylpyrimidin-2-(1H)-ones not 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones. The advantage of this… read more here.
Keywords: pot synthesis; catalyzed one; one pot; diarylpyrimidin ones ... See more keywords
Cu/Fe/O=PPh3-catalyzed etherification for the synthesis of aryl 3-benzo[b]thienyl ethers
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DOI: 10.1246/cl.180425
Abstract: Cu/Fe-cocatalyzed cross-coupling reactions between 3-bromobenzo[b]thiophene and hydroxyaryls are described herein. The combination of Cu and Fe catalysts is important for the progress of the reacti... read more here.
Keywords: etherification synthesis; benzo thienyl; catalyzed etherification; aryl benzo ... See more keywords
Pd(PPh3)4 Catalyzed Synthesis of Indazole Derivatives as Potent Anticancer Drug
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DOI: 10.3390/app10113792
Abstract: A series of 3-aryl indazoles and 1-methyl-3-aryl indazole derivatives are prepared with exceptional yields by coupling with several arylboronic acids and methylation by two dissimilar approaches. The as-prepared indazole derivatives (3a–3j) and their N-methyl derivatives… read more here.
Keywords: synthesis indazole; derivatives potent; potent anticancer; pph3 catalyzed ... See more keywords