Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800716
Abstract: Protein–protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650 000 PPIs underlie the human interactome; thus underscoring its complexity and the manifold signaling outputs altered in response… read more here.
Keywords: ppi; fourth wall; drug; drug discovery ... See more keywords
Ticagrelor monotherapy after coronary stenting in patients requiring proton pump inhibitor and prolonged antiplatelet therapy
Sign Up to like & getrecommendations! Published in 2022 at "Catheterization and Cardiovascular Interventions"
DOI: 10.1002/ccd.30315
Abstract: The ischemic and bleeding event risk trade‐off must be managed after coronary stenting. Prophylactic or continued proton pump inhibitor (PPI) therapy is often prescribed in addition to antiplatelet therapy. Almost half of the patients undergoing… read more here.
Keywords: therapy; placebo; ppi; monotherapy ... See more keywords
PPI‐Induced Changes in Plasma Metabolite Levels Influence Total Hip Bone Mineral Density in a UK Cohort
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4754
Abstract: Proton pump inhibitors (PPIs) are among the most used drugs in the UK. PPI use has been associated with decreased bone mineral density (BMD) and increased fracture risk, although these results have been inconsistent. We… read more here.
Keywords: ppi; bone mineral; mineral density; total hip ... See more keywords
Controlled Synthesis, Chiral Assembly, and Circularly Polarized Luminescence of Poly(phenyl isocyanide)-block-Polyfluorene Copolymers.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular rapid communications"
DOI: 10.1002/marc.202300159
Abstract: In this work, π-conjugated block copolymers consisting of poly(phenyl isocyanide) (PPI) and polyfluorene (PF) segments were facilely prepared by one-pot sequential polymerization of phenyl isocyanide (monomer 1) and 7-bromo-9,9-dioctylfluorene-2-boronic acid pinacol ester (monomer 2). The… read more here.
Keywords: poly phenyl; phenyl isocyanide; ppi; block ... See more keywords
Use of proton pump inhibitors in adults in France: a nationwide drug utilization study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-019-02810-1
Abstract: Purpose Proton pump inhibitor (PPI) drugs are approved for the management of gastric acid–related diseases, mainly treatment of gastroesophageal reflux disease, treatment of nonsteroidal anti-inflammatory drugs (NSAID)–related gastrointestinal complications and prevention in at-risk patients, Helicobacter… read more here.
Keywords: ppi; treatment; new users; ppi users ... See more keywords
EANM commitment towards involvement and engagement of patients and the public: learning from the UK experience
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04457-7
Abstract: Commonly referred to as patient/public involvement and engagement (PPI/E) as well as user involvement or lay involvement, PPI/E incorporates and integrates individual’s perspectives in the planning and improvement of healthcare services and research [2, 3].… read more here.
Keywords: medicine; involvement engagement; research; ppi ... See more keywords
Impingement of the patellar component against the tibial post after posterior stabilized and constrained TKA: a pilot study
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Orthopaedic and Trauma Surgery"
DOI: 10.1007/s00402-017-2682-2
Abstract: IntroductionPatella-post impingement (PPI), contact of the patellar component with the tibial post, occurs during deep knee flexion after posterior stabilized total knee arthroplasty (TKA). PPI can cause anterior knee pain, increased patellar pressure, wear of… read more here.
Keywords: component tibial; tibial post; ppi; patellar component ... See more keywords
The effects of multiphasic prepulses on automatic and attention-modulated prepulse inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Cognitive Processing"
DOI: 10.1007/s10339-017-0808-7
Abstract: Prepulse inhibition (PPI) is widely viewed as an operational measure of sensorimotor gating. Previous research has shown that sensorimotor gating can occur automatically and also can be influenced by selective attention. The present research investigated… read more here.
Keywords: multiphasic prepulses; automatic attention; ppi; prepulse inhibition ... See more keywords
Identification of potential prognostic biomarkers for breast cancer using WGCNA and PPI integrated techniques.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2020.151675
Abstract: In this study, we aimed to detect promising prognostic factors of breast cancer and interpreted the relevant mechanisms using an integrated bioinformatics analysis. RNA sequencing profile of breast cancer was downloaded from The Cancer Genome… read more here.
Keywords: ppi; analysis; breast cancer; expression ... See more keywords
Antagonistic interactions between osterix and pyrophosphate during cementum formation.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.05.001
Abstract: During cementum formation, the key roles of osterix (Osx) and inorganic pyrophosphate (PPi), mainly controlled by nucleotide pyrophosphatase 1 (Npp1; encoded by the Enpp1 gene) and progressive ankylosis protein (Ank), have been demonstrated by animal… read more here.
Keywords: ppi; cementum; cementum formation; expression ... See more keywords
Proton pump inhibitors on pancreatic cancer risk and survival.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer epidemiology"
DOI: 10.1016/j.canep.2016.12.006
Abstract: BACKGROUND Hypergastrinemia may promote the development and progression of pancreatic cancer. Proton pump inhibitor (PPI) therapy is known to cause hypergastrinemia. We sought to determine the association between PPI therapy and the risk of developing… read more here.
Keywords: ppi; study; pancreatic cancer; cancer risk ... See more keywords