Protein–protein interaction network of E. coli K‐12 has significant high‐dimensional cavities: new insights from algebraic topological studies
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13437
Abstract: As a model system, Escherichia coli has been used to study various life processes. A dramatic paradigm shift has occurred in recent years, with the study of single proteins moving toward the study of dynamically interacting… read more here.
Keywords: network; dimensional cavities; ppi network; high dimensional ... See more keywords
Identifying protein complexes in PPI network using non-cooperative sequential game
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DOI: 10.1038/s41598-017-08760-x
Abstract: Identifying protein complexes from protein-protein interaction (PPI) network is an important and challenging task in computational biology as it helps in better understanding of cellular mechanisms in various organisms. In this paper we propose a… read more here.
Keywords: game; network; identifying protein; ppi network ... See more keywords
Fractional diffusion on the human proteome as an alternative to the multi-organ damage of SARS-CoV-2
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DOI: 10.1063/5.0015626
Abstract: The coronavirus 2019 (COVID-19) respiratory disease is caused by the novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), which uses the enzyme ACE2 to enter human cells. This disease is characterized by important damage… read more here.
Keywords: fractional diffusion; damage; multi organ; sars cov ... See more keywords
A New Scheme for Essential Protein Identification Based on Uncertain Networks
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DOI: 10.1109/access.2020.2974897
Abstract: Identifying essential proteins is important for not only understanding cellular activity but also detecting human disease genes. A series of centrality measures have been proposed to identify essential proteins based on the protein-protein interaction (PPI)… read more here.
Keywords: ppi network; new scheme; essential protein; essential proteins ... See more keywords
Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics
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DOI: 10.1155/2019/3739086
Abstract: Acne is the eighth most frequent disease worldwide. Inflammatory response runs through all stages of acne. It is complicated and is involved in innate and adaptive immunity. This study aimed to explore the candidate genes… read more here.
Keywords: degs; analysis; pathogenesis; pathways involved ... See more keywords
Ranking Cancer Proteins by Integrating PPI Network and Protein Expression Profiles
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DOI: 10.1155/2019/3907195
Abstract: Proteomics, the large-scale analysis of proteins, is contributing greatly to understanding gene function in the postgenomic era. However, disease protein ranking using shotgun proteomics data has not been fully evaluated. In this study, we prioritized… read more here.
Keywords: proteins integrating; network; network protein; expression ... See more keywords
Identification of the Hub Genes in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2021 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2021/6329041
Abstract: Purpose Alzheimer's disease (AD) is considered to be the most common neurodegenerative disease and also one of the major fatal diseases affecting the elderly, thus bringing a huge burden to society. Therefore, identifying AD-related hub… read more here.
Keywords: identification hub; alzheimer disease; hub genes; disease ... See more keywords
Identification of Key Genes and Immune Infiltrate in Nonalcoholic Steatohepatitis: A Bioinformatic Analysis
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/7561645
Abstract: Background Nonalcoholic steatohepatitis (NASH) can progress to cirrhosis and hepatic carcinoma and is closely associated with changes in the neurological environment. The discovery of new biomarkers would aid in the treatment of NASH. Methods Data… read more here.
Keywords: nonalcoholic steatohepatitis; analysis; genes immune; key genes ... See more keywords
Bioinformatics Study Identified EGF as a Crucial Gene in Papillary Renal Cell Cancer
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DOI: 10.1155/2022/4761803
Abstract: Background Due to a lack of knowledge of the disease process, papillary renal cell carcinoma (PRCC) has a dismal outlook. This research was aimed at uncovering the possible biomarkers and the underlying principles in PRCC… read more here.
Keywords: hub genes; renal cell; ppi network; papillary renal ... See more keywords
Proteomics Reveals Molecular Changes in Insomnia Patients with More Dreams
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DOI: 10.1155/2022/6181943
Abstract: Background Insomnia is a sleep disorder and the cause of many healthy problems. However, there are few studies on patients with insomnia and dreaminess at present. Therefore, this study is aimed at exploring the pathological… read more here.
Keywords: insomnia patients; ppi network; patients dreams; reveals molecular ... See more keywords
Quantitative Proteomic Profiling Identifies Differentially Regulated Pathways in Fanconi Anemia and Aplastic Anemia
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DOI: 10.1182/blood-2018-99-116347
Abstract: Purpose: Prognosis and therapeutic treatment of Fanconi anemia (FA) and acquired aplastic anemia (AA) are different. However, delayed and incorrect treatments are frequently occurred in FA because its symptoms are very similar to those of… read more here.
Keywords: quantitative proteomic; aplastic anemia; anemia; fanconi anemia ... See more keywords