Legionella pneumophila PPIase Mip Interacts with the Bacterial Proteins SspB, Lpc2061, and FlaA and Promotes Flagellation
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DOI: 10.1128/iai.00276-22
Abstract: The peptidyl-prolyl-cis/trans-isomerase (PPIase) macrophage infectivity potentiator (Mip) contributes to the pathogenicity and fitness of L. pneumophila, the causative agent of Legionnaires’ disease. Here, we identified the stringent starvation protein SspB, hypothetical protein Lpc2061, and flagellin… read more here.
Keywords: lpc2061 flaa; interaction partners; flagellation; ppiase ... See more keywords
Thermococcus sp. KS-1 PPIase as a fusion partner improving soluble production of aromatic amino acid decarboxylase
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DOI: 10.1186/s13568-021-01340-3
Abstract: Peptidyl-prolyl cis - trans isomerase (PPIase, EC 5.2.1.8) catalyzes the racemization reaction of proline residues on a polypeptide chain. This enzyme is also known to function as a molecular chaperon to stabilize protein conformation during… read more here.
Keywords: aromatic amino; amino acid; acid decarboxylase; strain ... See more keywords
Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity
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DOI: 10.3389/fphar.2018.00126
Abstract: Cyclophilin J (CyPJ), also called peptidylprolyl isomerase like 3, has been identified as a novel member of the cyclophilin family. Our previous research has resolved the three-dimensional structure of CyPJ and demonstrated the peptidylprolyl cis–trans… read more here.
Keywords: cypj; cyclophilin; inhibition; quinoxaline amine ... See more keywords