Inappropriateness of Proton Pump Inhibitors After Hospital Discharge Is Associated with Thirty-Day Hospital Readmission
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-021-06909-3
Abstract: Concerns have been raised about the adverse effects of proton pump inhibitors (PPIs). Rather than PPIs themselves causing harm, we hypothesized that PPIs prescribed without appropriate indications would be associated with adverse outcomes compared to… read more here.
Keywords: ppis; readmission; day hospital; hospital readmission ... See more keywords
Impact of pharmacist-evaluated clinical decision support system alerts on potentially missing or inappropriately prescribed proton pump inhibitors at hospital discharge: a retrospective cross-sectional study
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-024-01746-6
Abstract: Proton pump inhibitors (PPIs) are among the most prescribed drugs. A clinical decision support system (CDSS) could improve their rational use. The impact of an electronic algorithm (e-algorithm) implemented in a CDSS on potentially missing… read more here.
Keywords: proton pump; ppis; clinical decision; sensitivity ... See more keywords
Muscular Adverse Drug Reactions Associated with Proton Pump Inhibitors: A Disproportionality Analysis Using the Italian National Network of Pharmacovigilance Database
Sign Up to like & getrecommendations! Published in 2017 at "Drug Safety"
DOI: 10.1007/s40264-017-0564-8
Abstract: IntroductionProton pump inhibitors (PPIs) have been implicated in the occurrence of moderate to severe myopathies in several case reports.AimThis study was performed to assess the reporting risk of muscular adverse drug reactions (ADRs) associated with… read more here.
Keywords: ppis; disproportionality; muscular adrs; analysis ... See more keywords
A tandem near-infrared fluorescence complementation system with enhanced fluorescence for imaging protein-protein interactions in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120544
Abstract: Bimolecular fluorescence complementation (BiFC) is an effective tool for visualizing protein-protein interactions (PPIs). However, a BiFC system with long wavelength and high fluorescence intensity is yet to be developed for in vivo imaging. In this… read more here.
Keywords: protein; ppis; system; fluorescence ... See more keywords
In silico-prediction of protein–protein interactions network about MAPKs and PP2Cs reveals a novel docking site variants in Brachypodium distachyon
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33428-5
Abstract: Protein-protein interactions (PPIs) underlie the molecular mechanisms of most biological processes. Mitogen-activated protein kinases (MAPKs) can be dephosphorylated by MAPK-specific phosphatases such as PP2C, which are critical to transduce extracellular signals into adaptive and programmed… read more here.
Keywords: protein; ppis; protein interactions; novel docking ... See more keywords
The effect of proton pump inhibitors on the efficacy of nivolumab monotherapy in different types of cancer
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz338.107
Abstract: Abstract Background Solid tumors are characterized by a highly acidic microenvironment that might hamper anti-cancer immunity. Several studies have shown that proton pump inhibitors (PPIs) can neutralize the pH of the tumor microenvironment and indirectly… read more here.
Keywords: pump inhibitors; nivolumab monotherapy; types cancer; ppis ... See more keywords
The OncoPPi Portal: an integrative resource to explore and prioritize protein–protein interactions for cancer target discovery
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx743
Abstract: Motivation As cancer genomics initiatives move toward comprehensive identification of genetic alterations in cancer, attention is now turning to understanding how interactions among these genes lead to the acquisition of tumor hallmarks. Emerging pharmacological and… read more here.
Keywords: ppis; protein interactions; protein protein; oncoppi portal ... See more keywords
T188. MASSIVE OPEN ONLINE DISCOVERY ‘MOOD’ FOR SCHIZOPHRENIA RESEARCH
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby016.464
Abstract: Abstract Background We have recently presented Schizophrenia Interactome, i.e., the network of protein-protein interactions (PPIs) of schizophrenia associated genes. PPIs predicted by our High-precision Protein-Protein Interaction Prediction model (HiPPIP) which uses machine learning to classify… read more here.
Keywords: ppis; schizophrenia; research; biology ... See more keywords
F200. ELUCIDATING THE ROLE OF CILIA IN NEUROPSYCHIATRIC DISEASES THROUGH INTERACTOME ANALYSIS
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby017.731
Abstract: Abstract Background Cilia are microtubule-based organelles present on the surface of many eukaryotic cell types critical for tissue homeostasis and proper organ development. Ciliary dysfunction underlies a growing list of human diseases and disorders collectively… read more here.
Keywords: ppis; schizophrenia; neuropsychiatric diseases; disorder ... See more keywords
Proton Pump Inhibitors and the Risk of Osseointegrated Dental Implant Failure: A Cohort Study
Sign Up to like & getrecommendations! Published in 2017 at "Clinical Implant Dentistry and Related Research"
DOI: 10.1111/cid.12455
Abstract: Proton pump inhibitors (PPIs) have a negative impact on bone accrual. Because osseointegration is influenced by bone metabolism, this study investigates the association between PPIs and the risk of osseointegrated implant failure. This retrospective cohort… read more here.
Keywords: ppis; risk osseointegrated; dental implant; implant failure ... See more keywords
Reply to: Proton Pump Inhibitors and Risk of Pneumonia in Individuals with Dementia
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Geriatrics Society"
DOI: 10.1111/jgs.15084
Abstract: To the Editor: I have read the article of Ho and colleagues with great interest. They found that individuals with dementia are more prone to develop pneumonia when using long-term proton pump inhibitors (PPIs) than… read more here.
Keywords: pump inhibitors; ppis; long term; using ppis ... See more keywords