Novel combinations of experimental and computational analysis tested on the binding of metalloprotoporphyrins to albumin.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.05.060
Abstract: The evidence that Human Serum Albumin (HSA) binds metal ions and organometallic compounds has generated interest in its physiological role as a metalloprotein and as a vehicle for synthetic biology applications (e.g., synthetic blood and… read more here.
Keywords: combinations experimental; computational analysis; binding; ppix ... See more keywords
Plasma membrane activatable polymeric nanotheranostics with self‐enhanced light‐triggered photosensitizer cellular influx for photodynamic cancer therapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2017.04.030
Abstract: &NA; To address the issue of low cellular uptake of photosensitizers by cancer cells in photodynamic therapy (PDT), we designed a smart plasma membrane‐activatable polymeric nanodrug by conjugating the photosensitizer protoporphyrin IX (PpIX) and polyethylene… read more here.
Keywords: ppix; activatable polymeric; membrane; membrane activatable ... See more keywords
Plasma membrane‐anchorable photosensitizing nanomicelles for lipid raft‐responsive and light‐controllable intracellular drug delivery
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.07.027
Abstract: ABSTRACT The past decade has witnessed a growing number of nanoparticulate drug delivery systems for cancer treatment. However, insufficient cellular uptake by cancer cells and the undesirable endo/lysosomal entrapment of internalized therapeutic drugs remain the… read more here.
Keywords: delivery; drug; ppix; peg ppix ... See more keywords
Lack of effect of selected sunscreens applied on ex vivo human skin for 5-methyl-aminolevulinic acid penetration and protoporphyrin IX photoactivation.
Sign Up to like & getrecommendations! Published in 2017 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2016.11.012
Abstract: BACKGROUND Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers. Methyl-aminolevulinate (MAL) is metabolized to protoporphyrin IX (PpIX) which accumulates in the skin lesion and which generates a painful photochemical toxic reaction upon… read more here.
Keywords: penetration; skin; human skin; ppix ... See more keywords
Inactivation of protoporphyrin IX in erythrocytes in patients with erythropoietic protoporphyria: a new treatment modality.
Sign Up to like & getrecommendations! Published in 2019 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2019.101582
Abstract: BACKGROUND Erythropoietic protoporphyria (EPP) is a rare, genetic disease with reduced ferrochelatase activity causing protoporphyrine IX (PpIX) to accumulate in erythrocytes. PpIX activation by daylight causes skin erythema, edema, burning, and stinging. No treatment exists… read more here.
Keywords: erythropoietic protoporphyria; protoporphyrin erythrocytes; treatment; erythrocytes patients ... See more keywords
Trends in erythrocyte protoporphyrin IX concentration by age, sex and season among patients with erythropoietic protoporphyria - 20 years of follow-up.
Sign Up to like & getrecommendations! Published in 2020 at "Photodiagnosis and photodynamic therapy"
DOI: 10.1016/j.pdpdt.2020.101928
Abstract: BACKGROUND Erythropoietic protoporphyria (EPP) is an inherited disorder leading to an increased concentration of the photoactive protoporphyrin IX (PpIX) in erythrocytes. Upon photoactivation in the dermal blood vessels and release to the skin it causes… read more here.
Keywords: erythrocyte ppix; erythropoietic protoporphyria; age; ppix ... See more keywords
Results of a pilot study of isoniazid in patients with erythropoietic protoporphyria.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular genetics and metabolism"
DOI: 10.1016/j.ymgme.2019.07.017
Abstract: Erythropoietic protoporphyria (EPP), the most common porphyria of childhood and the third most common porphyria of adulthood, is characterized clinically by painful, non-blistering cutaneous photosensitivity. Two distinct inheritance patterns involving mutations affecting genes that encode… read more here.
Keywords: study isoniazid; erythropoietic protoporphyria; results pilot; pilot study ... See more keywords
Hydroxypyridinone and 5-Aminolaevulinic Acid Conjugates for Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00346
Abstract: Photodynamic therapy (PDT) is a promising treatment strategy for malignant and nonmalignant lesions. 5-Aminolaevulinic acid (ALA) is used as a precursor of the photosensitizer, protoporphyrin IX (PpIX), in dermatology and urology. However, the effectiveness of… read more here.
Keywords: hydroxypyridinone; ppix; photodynamic therapy; aminolaevulinic acid ... See more keywords
Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-30247-6
Abstract: Protoporphyrin IX (PpIX) induced by 5-aminolevulinic acid (5-ALA) is increasingly used as a fluorescent marker for fluorescence-guided resection of malignant gliomas. Understanding how the properties of the excitation light source and PpIX fluorescence interact with… read more here.
Keywords: fluorescence; optical characterization; ppix; operating microscopes ... See more keywords
Effects of the tumour microenvironment on protoporphyrin IX accumulation in glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab195.051
Abstract: Glioblastoma is the most common primary brain tumour and has a poor prognosis. Standard clinical intervention involves the resection of the tumour volume, chemotherapy and radiotherapy. However, achieving gross-total resection is challenging due to poorly… read more here.
Keywords: microenvironment; accumulation; glioblastoma; exogenous ala ... See more keywords
A Broad-Spectrum Antiviral Molecule, Protoporphyrin IX, Acts as a Moderator of HIV-1 Capsid Assembly by Targeting the Capsid Hexamer
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02663-22
Abstract: CA and its assembled viral core play essential roles in distinct steps during HIV-1 replication, including reverse transcription, integration, nuclear entry, virus assembly, and maturation through CA–CA or CA–host factor interactions. These functions of CA… read more here.
Keywords: hiv; ppix; molecule protoporphyrin; hexamer ... See more keywords