Solid self‐nanoemulsifying drug delivery systems for oral delivery of polypeptide‐k: Formulation, optimization, in‐vitro and in‐vivo antidiabetic evaluation
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.08.022
Abstract: &NA; Development of self‐nanoemulsifying drug delivery systems (SNEDDS) of polypeptide‐k (PPK) is reported with the aim to achieve its oral delivery. Box‐Behnken design (BBD) was adopted to develop and optimize the composition of SNEDDS. Oleoyl… read more here.
Keywords: oral delivery; delivery; formulation; drug ... See more keywords
Population Pharmacokinetic Analysis of Drug-Drug Interactions Between Perampanel and Carbamazepine Using Enzyme Induction Model in Epileptic Patients.
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DOI: 10.1097/ftd.0000000000001055
Abstract: BACKGROUND Perampanel (PER) is an oral antiepileptic drug and its concomitant use with carbamazepine (CBZ) leads to decreased PER concentrations. However, the magnitude of its influence may vary, depending on the dynamics of the enzyme… read more here.
Keywords: error; ppk; model; enzyme induction ... See more keywords
Mild collodion baby as a presenting sign of loricrin keratoderma: report of a case and review of the literature
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DOI: 10.1111/ced.14103
Abstract: A 12-day-old boy presented with cutaneous anomalies that had been present since birth. He was the first child of unrelated white parents, and had been born at gestational week 37 after an uneventful delivery. Physical… read more here.
Keywords: loricrin keratoderma; presenting sign; collodion baby; mild collodion ... See more keywords
Angiosarcoma-related pneumohemothorax treated with intrapleural paclitaxel administration and pleurodesis with OK-432
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Dermatology"
DOI: 10.1684/ejd.2018.3318
Abstract: EJD, vol. 28, n◦ 4, July-August 2018 In 2008, NPPK was characterized as an entity distinct from Meleda disease, based on its milder clinical manifestations and lack of associated SLURP-1 mutations [3]. In the initial… read more here.
Keywords: angiosarcoma related; pneumohemothorax treated; nppk; related pneumohemothorax ... See more keywords
The recommended dosage regimen for caspofungin in patients with higher body weight or hypoalbuminaemia will result in low exposure: Five years of data based on a population pharmacokinetic model and Monte-Carlo simulations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.993330
Abstract: Background: To develop a population pharmacokinetic (PPK) model for caspofungin, identify parameters influencing caspofungin pharmacokinetics, and assess the required probability of target attainment (PTA) and cumulative fraction of response (CFR) for various dosing regimens of… read more here.
Keywords: caspofungin patients; body weight; ppk; model ... See more keywords
The Phosin PptA Plays a Negative Role in the Regulation of Antibiotic Production in Streptomyces lividans
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DOI: 10.3390/antibiotics10030325
Abstract: In Streptomyces, antibiotic biosynthesis is triggered in phosphate limitation that is usually correlated with energetic stress. Polyphosphates constitute an important reservoir of phosphate and energy and a better understanding of their role in the regulation… read more here.
Keywords: regulation antibiotic; antibiotic production; ppta; role regulation ... See more keywords