1324. Target Attainment of Exebacase, a First-In-Class Antibacterial Lysin, to Determine Optimal Doses for Adult Patients with Staphylococcus aureus (S. aureus) Bloodstream Infections (Bacteremia) Including Endocarditis
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DOI: 10.1093/ofid/ofaa439.1506
Abstract: Exebacase, a novel, antibacterial direct lytic agent for the treatment of S. aureus bacterimia and endocarditis, studied in Phase 1 and 2 trials, demonstrated potential to improve clinical outcomes when used in addition to conventional… read more here.
Keywords: target attainment; ppk model; consultant; exebacase ... See more keywords
1340. Population Pharmacokinetic (PK) Analysis of APX001 Using Phase 1 Data
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DOI: 10.1093/ofid/ofy210.1172
Abstract: Abstract Background APX001 is a novel antifungal agent which is rapidly converted to the active metabolite APX001A. APX001A exhibits in vitro activity against many clinically important yeast and fungi, including echinocandin- and azole-resistant Candida species.… read more here.
Keywords: research; apx001; amplyx pharmaceuticals; ppk model ... See more keywords
Population Pharmacokinetics and AUC‐Based Dose Optimization of Vancomycin in Chinese Neonates
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DOI: 10.1155/jcpt/6935260
Abstract: Objective: The primary objective of this study revolves around the development of a population pharmacokinetic (PPK) model for vancomycin in neonatal subjects, with the objective of providing a theoretical basis for judicious therapeutic interventions.Methods: In… read more here.
Keywords: neonatal patients; gestational age; ppk model; model ... See more keywords
Development of a population pharmacokinetic (PPK) model of intravenous (IV) trastuzumab in patients with a variety of solid tumors to support dosing and treatment recommendations.
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DOI: 10.1200/jco.2017.35.15_suppl.2525
Abstract: 2525Background: The aim of this analysis was to develop a PPK model for IV trastuzumab (Herceptin), to assess the impact of patient covariates on PK, and perform simulations to support dosing recommendations. Methods: Serum trastuzumab… read more here.
Keywords: development population; support dosing; ppk model; trastuzumab ... See more keywords
Development and Validation of a Population Pharmacokinetics Model of Perampanel for Pediatric Epilepsy Patients for Optimized Dosing
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DOI: 10.2147/dddt.s499085
Abstract: Background Perampanel exhibits substantial interindividual variability, and pharmacokinetic data in pediatric patients are scarce. The aim of this study was to develop a population pharmacokinetic (PPK) model to optimize the dosing of perampanel in children… read more here.
Keywords: ppk model; pediatric patients; population; development validation ... See more keywords
A Population Pharmacokinetics Model of Busulfan in Pediatric Patients with Thalas-semia Major.
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DOI: 10.2174/0113892002402673251003055700
Abstract: Purpose: This research aimed to establish a population pharmacokinetic (PPK) model for busulfan (Bu) in Chinese pediatric patients with thalassemia major. We analyzed pharmacokinetic (PK) parameter variability and explored potential covariates affecting Bu disposition using… read more here.
Keywords: model busulfan; ppk model; pediatric patients; population ... See more keywords
Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients
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DOI: 10.3389/fphar.2024.1524272
Abstract: Objectives To assess the pharmacokinetics and pharmacodynamics of imipenem in a retrospective cohort of hospitalized Chinese older patients. Methods A population pharmacokinetic (PPK) model was constructed utilizing a nonlinear mixed-effects modeling approach. The final model… read more here.
Keywords: elderly patients; every every; ppk model; population ... See more keywords