Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia
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DOI: 10.1038/s41375-024-02296-6
Abstract: Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy with a fulminant clinical course. Our previous study revealed that ANKL cells proliferate predominantly in the liver sinusoids and strongly depend on transferrin supplementation.… read more here.
Keywords: sensitivity ppmx; ppmx t003; leukemia; amino ... See more keywords
Use of Ppmx-T003 As a Potent Inhibitor of Erythrocytosis in Polycythemia Vera
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DOI: 10.1182/blood-2020-138387
Abstract: Iron incorporation through transferrin (Tf) and its receptor, TfR1, plays a critical role in erythropoiesis. We hypothesized that blockade of TfR1 may be a promising strategy to suppress erythrocytosis observed in polycythemia vera (PV). To… read more here.
Keywords: tfr1; ppmx t003; ltd; japan ... See more keywords