Oncogenic K‐RasG12V cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts
Sign Up to like & getrecommendations! Published in 2024 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13775
Abstract: Protein phosphatase 6 is a Ser/Thr protein phosphatase and its catalytic subunit is Ppp6c. Ppp6c is thought to be indispensable for proper growth of normal cells. On the other hand, loss of Ppp6c accelerates growth… read more here.
Keywords: proliferation failure; loss ppp6c; ppp6c; proliferation ... See more keywords
PP6 deficiency in mice with KRAS mutation and Trp53 loss promotes early death by PDAC with cachexia‐like features
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DOI: 10.1111/cas.15315
Abstract: To examine effects of PP6 gene (Ppp6c) deficiency on pancreatic tumor development, we developed pancreas‐specific, tamoxifen‐inducible Cre‐mediated KP (KRAS(G12D) plus Trp53‐deficient) mice (cKP mice) and crossed them with Ppp6cflox/flox mice. cKP mice with the homozygous… read more here.
Keywords: early death; ppp6c; ckp mice; mice ... See more keywords
208-OR: PPP6C Directly Dephosphorylates TSC2, Improves Hepatic Lipid Metabolism, and Mediates FGF21 Action on Metabolic Dysfunction–Associated Steatohepatitis in Mice
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DOI: 10.2337/db25-208-or
Abstract: Introduction and Objective: Metabolic dysfunction-associated steatohepatitis (MASH) is a serious chronic liver disease and remains limited therapies. Although fibroblast growth factor 21 (FGF21) has shown promising therapeutic benefits for MASH, how FGF21 signals are transduced… read more here.
Keywords: mice; none; dysfunction associated; associated steatohepatitis ... See more keywords