The toxic effects of yeast Ppz1 phosphatase are counteracted by subcellular relocalization mediated by its regulatory subunit Hal3
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DOI: 10.1002/1873-3468.14330
Abstract: Overexpression of Saccharomyces cerevisiae protein phosphatase Ppz1 strongly impairs cell growth. Ppz1 is negatively regulated by its subunit Hal3, and Hal3 overexpression fully counteracts the toxic effects derived from high levels of the phosphatase. We show… read more here.
Keywords: phosphatase; hal3; subunit hal3; ppz1 ... See more keywords
When Phosphatases Go Mad: The Molecular Basis for Toxicity of Yeast Ppz1
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DOI: 10.3390/ijms23084304
Abstract: The fact that overexpression of the yeast Ser/Thr protein phosphatase Ppz1 induces a dramatic halt in cell proliferation was known long ago, but only work in the last few years has provided insight into the… read more here.
Keywords: phosphatases mad; toxicity; ppz1; basis toxicity ... See more keywords