The PqsE Active Site as a Target for Small Molecule Antimicrobial Agents against Pseudomonas aeruginosa
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DOI: 10.1021/acs.biochem.2c00334
Abstract: The opportunistic pathogen Pseudomonas aeruginosa causes antibiotic resistant, nosocomial infections in immuno-compromised individuals, and is a high priority for antimicrobial development. Key to pathogenicity in P. aeruginosa are biofilm formation and virulence factor production. Both… read more here.
Keywords: interaction; pseudomonas aeruginosa; pqse rhlr; rhlr interaction ... See more keywords
Protein Interaction Networks of Catalytically Active and Catalytically Inactive PqsE in Pseudomonas aeruginosa
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DOI: 10.1128/mbio.01559-22
Abstract: Pseudomonas aeruginosa causes hospital-borne infections in vulnerable patients, including immunocompromised individuals, burn victims, and cancer patients undergoing chemotherapy. There are no effective treatments for P. aeruginosa infections, which are usually broadly resistant to antibiotics. ABSTRACT… read more here.
Keywords: interaction; rhlr; pseudomonas aeruginosa; quorum sensing ... See more keywords
[Perifosine inhibits biofilm formation of Pseudomonas aeruginosa by interacting with PqsE protein].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]"
DOI: 10.3760/cma.j.cn112150-20211020-00970
Abstract: To explore the biofilm inhibitory efficacy of perifosine against Pseudomonas aeruginosa (P. aeruginos) and its mechanisms. Twenty-fourwell plate was used to form biofilms at the bottom and crystal violet staining was used to determine the… read more here.
Keywords: without perifosine; effects perifosine; wells without; perifosine ... See more keywords