Practical Access to Trisubstituted Morita‐Baylis‐Hillman‐Type Products Through Copper‐catalyzed Reductive Aldol Reactions of Alkynones
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DOI: 10.1002/ajoc.202400422
Abstract: We report a convenient and diastereoselective copper‐catalyzed reductive alkynone aldol addition to aldehydes, with pinacolborane as stoichiometric reductant, that results in the generation of densely functionalized, trisubstituted (Z)‐enone products analogous to Morita‐Baylis‐Hillman adducts. We demonstrate… read more here.
Keywords: aldol; practical access; morita baylis; baylis hillman ... See more keywords
A practical access to fluoroalkylthio(seleno)-functionalized bicyclo[1.1.1]pentanes
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DOI: 10.1007/s11426-020-9733-y
Abstract: Rational design of new bioisosteres through introduction of high-value functional groups to bicyclo[1.1.1]pentane (BCP) is of particular use for drug discovery. Disclosed herein is the first access to valuable fluoroalkylthio(seleno)-functionalized BCPs. A range of SCF… read more here.
Keywords: fluoroalkylthio seleno; seleno functionalized; practical access;