Pragmatic Trials in Long-Term Care: Research Challenges and Potential Solutions in Relation to Key Areas of Care.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Medical Directors Association"
DOI: 10.1016/j.jamda.2021.12.011
Abstract: As a method of research, pragmatic trials are recommended so as to generate results that are applicable to real-world care. This intent is especially important for the millions of older adults who receive long-term care… read more here.
Keywords: term care; trials long; care; long term ... See more keywords
A search filter to identify pragmatic trials in MEDLINE was highly specific but lacked sensitivity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2020.05.003
Abstract: OBJECTIVE Identifying pragmatic trials from among all randomized trials is challenging because of inconsistent reporting. Our objective was to develop and validate a search filter to identify reports of pragmatic trials from Ovid MEDLINE. STUDY… read more here.
Keywords: sensitivity; search filter; filter identify; pragmatic trials ... See more keywords
Pilot and feasibility studies for pragmatic trials have unique considerations and areas of uncertainty.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical epidemiology"
DOI: 10.1016/j.jclinepi.2021.06.029
Abstract: BACKGROUND AND OBJECTIVE Feasibility studies are increasingly being used to support the development of, and investigate uncertainties around, future large-scale trials. The future trial can be designed with either a pragmatic or explanatory mindset. Whereas… read more here.
Keywords: trial; uncertainty; feasibility studies; feasibility ... See more keywords
Pragmatic trials of pain therapies: a systematic review of methods.
Sign Up to like & getrecommendations! Published in 2021 at "Pain"
DOI: 10.1097/j.pain.0000000000002317
Abstract: ABSTRACT Pragmatic randomised clinical trials aim to directly inform clinical or health policy decision making. Here, we systematically review methods and design of pragmatic trials of pain therapies to examine methods, identify common challenges, and… read more here.
Keywords: trials pain; therapies systematic; pain therapies; review methods ... See more keywords
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement.
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DOI: 10.1097/j.pain.0000000000002888
Abstract: ABSTRACT Many questions regarding the clinical management of people experiencing pain and related health policy decision-making may best be answered by pragmatic controlled trials. To generate clinically relevant and widely applicable findings, such trials aim… read more here.
Keywords: pragmatic trials; clinical trials; pain treatments; considerations pragmatic ... See more keywords
Pragmatic Trials in Long‐Term Care: Research Challenges and Potential Solutions in Relation to Key Areas of Care
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Geriatrics Society"
DOI: 10.1111/jgs.17699
Abstract: As a method of research, pragmatic trials are recommended so as to generate results that are applicable to real‐world care. This intent is especially important for the millions of older adults who receive long‐term care… read more here.
Keywords: long term; pragmatic trials; care; trials long ... See more keywords
Pragmatic trials: ignoring a mediator and adjusting for confounding
Sign Up to like & getrecommendations! Published in 2019 at "BMC Research Notes"
DOI: 10.1186/s13104-019-4188-1
Abstract: ObjectivesIn pragmatic trials, the new treatment is compared with usual care (heterogeneous control arm) that makes the comparison of the new treatment with each treatment within the control arm more difficult. The usual assumption is… read more here.
Keywords: ignoring mediator; trials ignoring; mediator; adjusting confounding ... See more keywords
Patient-reported outcomes and target effect sizes in pragmatic randomized trials in ClinicalTrials.gov: A cross-sectional analysis
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DOI: 10.1371/journal.pmed.1003896
Abstract: Background Use of patient-reported outcomes (PROs) and patient and public engagement are critical ingredients of pragmatic trials, which are intended to be patient centered. Engagement of patients and members of the public in selecting the… read more here.
Keywords: pragmatic trials; trial; patient public; engagement ... See more keywords