Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity
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DOI: 10.1091/mbc.e20-11-0747
Abstract: A network of chaperones and ubiquitin ligases sustain intracellular proteostasis and is integral in preventing aggregation of misfolded proteins associated with various neurodegenerative diseases. Using cell-based studies of polyglutamine (polyQ) diseases, spinocerebellar ataxia type 3… read more here.
Keywords: toxicity; polyglutamine; praja1 ubiquitin; degradation ... See more keywords