Growth inhibitor of human hepatic carcinoma HepG2 cells by evodiamine is associated with downregulation of PRAME
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01701-7
Abstract: Hepatocellular carcinoma (HCC) patients have low 5-year survival due to the delayed diagnosis, so it is necessary to develop an alternative treatment. Preferentially expressed antigen of melanoma (PRAME) has a high expression in HCC patients,… read more here.
Keywords: growth; prame; prame expression; hepg2 cells ... See more keywords
Immunohistochemical Expression of Preferentially Expressed Antigen in Melanoma (PRAME) in the Uninvolved Background Testis, Germ Cell Neoplasia in Situ, and Germ Cell Tumors of the Testis.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqab200
Abstract: OBJECTIVES Preferentially expressed antigen in melanoma (PRAME) has a key role in regulating pluripotency of primordial germ cells and in the development of germ cell tumors of the testis (GCTT). However, its immunohistochemical expression in… read more here.
Keywords: germ cell; expression; prame; germ ... See more keywords
Cytoplasmic expression of PMS2 (clone EP51), PRAME, and STAT6 (clone YE361) as a potential immunohistochemical finding for detection of sebocyte differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14100
Abstract: We have read with great interest the recent paper entitled “Comparison of adipophilin and recently introduced PReferentially expressed Antigen in MElanoma immunohistochemistry in the assessment of sebaceous neoplasms: a pilot study,” which reported the merit… read more here.
Keywords: clone; prame; pms2 clone; clone ep51 ... See more keywords
PRAME immunohistochemistry of spitzoid neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14245
Abstract: Spitzoid melanocytic neoplasms are well known to be diagnostically challenging. Immunohistochemistry (IHC) and molecular approaches have been used as ancillary diagnostic tests. Herein, we investigate the use of PRAME IHC for the assessment of spitzoid… read more here.
Keywords: prame; immunohistochemistry spitzoid; immunohistochemistry; pathology ... See more keywords
PRAME immunohistochemistry for melanoma diagnosis: A STARD‐compliant diagnostic accuracy study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14267
Abstract: Preferentially expressed antigen in melanoma (PRAME) is a tumor‐associated antigen that is frequently expressed in cutaneous melanoma and can be evaluated by immunohistochemistry. Earlier studies on PRAME utilized case‐control study designs that may misestimate diagnostic… read more here.
Keywords: prame; immunohistochemistry; melanoma; diagnostic accuracy ... See more keywords
Investigation of PRAME expression in lipid‐laden and non‐lipid‐laden cutaneous histiocytes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14334
Abstract: LCH, and xanthelasma, we determined a percentage based on staining in histiocytes. In DF and granulation tissues/scars, we determined a percentage based on staining in fibroblasts and histiocytes. The staining intensity was categorized as low… read more here.
Keywords: prame; expression lipid; investigation prame; lipid laden ... See more keywords
FLI‐1/Melan‐A dual stain is an alternative to PRAME in differentiating metastatic melanoma from nodal nevus: A monocentric retrospective study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cutaneous Pathology"
DOI: 10.1111/cup.14373
Abstract: Melanocytic nevi existing in lymph nodes create a diagnostic challenge by mimicking metastases. PReferentially expressed Antigen in MElanoma (PRAME) immunohistochemical (IHC) stain can differentiate one from another. FLI‐1 IHC expression has been shown in malignant… read more here.
Keywords: prame; melanoma; melan dual; fli melan ... See more keywords
Epitope Analysis of Murine and Chimeric Monoclonal Antibodies Recognizing the Cancer Testis Antigen PRAME
Sign Up to like & getrecommendations! Published in 2020 at "Doklady Biochemistry and Biophysics"
DOI: 10.1134/s1607672920030072
Abstract: Abstract We investigated the epitope specificity of different monoclonal antibodies recognizing the cancer testis antigen PRAME. Antibody 5D3 binds to the fragment of PRAME corresponding to 160–180 amino acid residues. Antibodies 6H8 and F11 bind… read more here.
Keywords: testis antigen; monoclonal antibodies; cancer testis; antibodies recognizing ... See more keywords
Analysis of PRAME immunocytochemistry in 109 acral malignant melanoma in situ
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Pathology"
DOI: 10.1136/jcp-2022-208697
Abstract: Aims Preferentially expressed antigen in melanoma (PRAME) recently is a reliable immunohistochemistry (IHC) marker for distinguishing melanoma from other lesions. However, there are few articles focused on PRAME use in acral malignant melanoma, the most… read more here.
Keywords: prame; melanoma situ; melanoma; malignant melanoma ... See more keywords
Abstract 3659: WT1 and PRAME mRNA transfected TLR 7/8-polarized fast DC vaccines in AML patients mount specific immune responses and impact progression free survival
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DOI: 10.1158/1538-7445.am2017-3659
Abstract: Patients diagnosed with acute myeloid leukemia (AML) may not be eligible for curative intensive treatment due to co-morbidity factors or age. Here we report results of 5 AML patients in morphological remission after incomplete induction/consolidation… read more here.
Keywords: aml patients; prame; specific immune; immune responses ... See more keywords
DC Vaccination Induces Antigen Specific Immune Responses in AML Patients: A 1-Year Interim Assessment
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DOI: 10.1182/blood-2019-129749
Abstract: Acute myeloid leukemia (AML) is a lethal hematological malignancy characterized by high rates of relapse (50%). Studies of immune responses in AML patients led to identification of two leukemia-associated antigens (Wilms' tumor protein 1 (WT1)… read more here.
Keywords: aml patients; prame; wt1 prame; gmbh employment ... See more keywords