M2‐polarized tumor‐associated macrophages promote epithelial‐mesenchymal transition via activation of the AKT3/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma
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DOI: 10.1002/jcb.29514
Abstract: Tumor‐associated macrophages (TAMs) have been considered as a major component of the tumor microenvironment. However, the crosstalk between M2‐polarized tumor‐associated macrophages (M2‐TAMs) and intrahepatic cholangiocarcinoma (ICC) remains undetermined. In the present study, we aimed to… read more here.
Keywords: pras40; tumor associated; intrahepatic cholangiocarcinoma; polarized tumor ... See more keywords
PRAS40 signaling in tumor
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DOI: 10.18632/oncotarget.17299
Abstract: The proline-rich Akt substrate of 40 kDa (PRAS40) is a substrate of Akt and a component of the mammalian target of rapamycin complex 1 (mTORC1). Locating at the crossroad of the PI3K/Akt pathway and the… read more here.
Keywords: signaling tumor; pras40 signaling; pras40; tumor ... See more keywords