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   Articles with "pravastatin" as a keyword



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Evaluation of Pharmacokinetic Drug Interactions of the Direct-Acting Antiviral Agents Elbasvir and Grazoprevir with Pitavastatin, Rosuvastatin, Pravastatin, and Atorvastatin in Healthy Adults

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recommendations! Published in 2021 at "Clinical Drug Investigation"

DOI: 10.1007/s40261-020-00974-8

Abstract: Many people infected with hepatitis C virus have comorbidities, including hypercholesterolemia, that are treated with statins. In this study, we evaluated the drug–drug interaction potential of the hepatitis C virus inhibitors elbasvir (EBR) and grazoprevir… read more here.

Keywords: ebr gzr; gzr; atorvastatin; drug ... See more keywords
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A Randomized Pilot Clinical Trial of Pravastatin Versus Placebo in Pregnant Patients at High-Risk of Preeclampsia.

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recommendations! Published in 2021 at "American journal of obstetrics and gynecology"

DOI: 10.1016/j.ajog.2021.05.018

Abstract: BACKGROUND Preeclampsia remains a major cause of maternal and neonatal morbidity and mortality. Biological plausibility, compelling preliminary data, and a pilot clinical trial support the safety and utility of pravastatin to prevent preeclampsia. OBJECTIVE We… read more here.

Keywords: clinical trial; trial; high risk; preeclampsia ... See more keywords
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Pravastatin may improve neurological outcome following low-grade aneurysmal subarachnoid hemorrhage

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recommendations! Published in 2022 at "Journal of Clinical Neuroscience"

DOI: 10.1016/j.jocn.2022.01.025

Abstract: Statins may improve outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH) but randomized controlled trials, including all patients with aSAH whatever their clinical severity, were negative. We studied whether pravastatin improved neurologic outcome in patients… read more here.

Keywords: outcome; subarachnoid hemorrhage; may improve; pravastatin ... See more keywords

Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies.

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recommendations! Published in 2017 at "Journal of reproductive immunology"

DOI: 10.1016/j.jri.2017.09.009

Abstract: Pre-eclampsia is a disease of pregnancy affecting 5%-8% of all pregnancies and a leading cause of maternal and fetal mortality. Despite improvements in the diagnosis, there is no effective method for prevention and treatment. While… read more here.

Keywords: pravastatin treat; treat prevent; prevent preeclampsia; pravastatin ... See more keywords
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Combination effect naringin and pravastatin in lipid profile and glucose in obese rats

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recommendations! Published in 2018 at "Life Sciences"

DOI: 10.1016/j.lfs.2017.11.044

Abstract: Aims: The purpose of this study was to compare the effect of naringin 100 mg/kg in combination with pravastatin 10 mg/kg by gavage for 6 weeks compared with monotherapy over lipid profiles, glucose levels and… read more here.

Keywords: naringin pravastatin; group; pravastatin; obesity ... See more keywords
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Pravastatin improves fetal survival in mice with a partial deficiency of heme oxygenase-1.

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recommendations! Published in 2019 at "Placenta"

DOI: 10.1016/j.placenta.2018.11.001

Abstract: INTRODUCTION Statins induce heme oxygenase-1 (HO-1) expression in vitro and in vivo. Low HO-1 expression is associated with pregnancy complications, e.g. preeclampsia and recurrent miscarriages. Here, we investigated the effects of pravastatin on HO-1 expression,… read more here.

Keywords: het; partial deficiency; pravastatin; mice ... See more keywords
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Computation-Aided Engineering of Cytochrome P450 for the Production of Pravastatin

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recommendations! Published in 2022 at "ACS Catalysis"

DOI: 10.1021/acscatal.2c03974

Abstract: CYP105AS1 is a cytochrome P450 from Amycolatopsis orientalis that catalyzes monooxygenation of compactin to 6-epi-pravastatin. For fermentative production of the cholesterol-lowering drug pravastatin, the stereoselectivity of the enzyme needs to be inverted, which has been… read more here.

Keywords: production; cytochrome p450; pravastatin; stereoselectivity ... See more keywords
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Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs

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recommendations! Published in 2022 at "Pharmaceutical Biology"

DOI: 10.1080/13880209.2022.2036767

Abstract: Abstract Context Patients with non-alcoholic steatohepatitis (NASH) may have a simultaneous intake of pravastatin and evodiamine-containing herbs. Objective The effect of evodiamine on the pharmacokinetics of pravastatin and its potential mechanisms were investigated in NASH… read more here.

Keywords: non alcoholic; evodiamine decreased; evodiamine; pravastatin ... See more keywords
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Pravastatin for prevention of HELLP syndrome

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recommendations! Published in 2017 at "Medicine"

DOI: 10.1097/md.0000000000008229

Abstract: Rationale: Pravastatin has emerged for prevention and treatment of preeclampsia; no reports are available on pravastatin and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome. Patient concerns: The first pregnancy necessitated termination of pregnancy… read more here.

Keywords: hellp syndrome; pregnancy; prevention hellp; pravastatin ... See more keywords
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Effect of statins on cardiovascular complications in chronic kidney disease patients

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recommendations! Published in 2020 at "Medicine"

DOI: 10.1097/md.0000000000020061

Abstract: Supplemental Digital Content is available in the text Abstract Background: The rates of cardiovascular mortality and morbidity are increased in advanced chronic kidney disease (CKD). Mild to moderate CKD is associated with an increase in… read more here.

Keywords: chronic kidney; cardiac events; effect; mortality ... See more keywords
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Combination therapy with cilostazol and pravastatin improves antiatherogenic effects in low‐density lipoprotein receptor knockout mice

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recommendations! Published in 2018 at "Cardiovascular Therapeutics"

DOI: 10.1111/1755-5922.12476

Abstract: AIMS Despite the therapeutic efficacy of statins and antiplatelet agents for atherosclerosis, monotherapy with each drug alone is often insufficient to achieve the patient's therapeutic goals. We previously showed that combined statin/antiplatelet agent/anti-tumor necrosis factor… read more here.

Keywords: pravastatin cilostazol; therapy; density lipoprotein; pravastatin ... See more keywords