The novel persistent sodium current inhibitor PRAX‐562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers
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DOI: 10.1111/epi.17149
Abstract: This study investigates the effects of PRAX‐562 on sodium current (INa), intrinsic neuronal excitability, and protection from evoked seizures to determine whether a preferential persistent INa inhibitor would exhibit improved preclinical efficacy and tolerability compared… read more here.
Keywords: sodium; inhibitor; sodium channel; prax 562 ... See more keywords