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   Articles with "prc1" as a keyword



Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202205573

Abstract: Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono-ubiquitination (H2AK119ub). BMI1 and RING1B are PRC1 core components and play critical roles in the development of various cancers.… read more here.

Keywords: bmi1 ring1b; protein complex; prc1; degradation ... See more keywords

CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.

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recommendations! Published in 2023 at "Environmental toxicology"

DOI: 10.1002/tox.23831

Abstract: BACKGROUND Circular RNA (circRNA) is considered an important molecular marker for the early diagnosis of tumors and a potential therapeutic target. Herein, we investigated the role and regulatory mechanism of circKDM1B in hepatocellular carcinoma (HCC).… read more here.

Keywords: hepatocellular carcinoma; mir 1322; hcc; circkdm1b ... See more keywords

Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.

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recommendations! Published in 2018 at "Developmental cell"

DOI: 10.1016/j.devcel.2018.11.018

Abstract: Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 have also been suggested, it has remained unclear whether Ub-dependent and -independent functions… read more here.

Keywords: fate restriction; repression; prc1; repression prc1 ... See more keywords

Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch.

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recommendations! Published in 2018 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2018.08.021

Abstract: Polycomb group proteins play essential roles in transcriptional gene repression during both animal and plant development. Polycomb repression complex 1 (PRC1) is one of the key functional modules in polycomb group silencing. It acts as… read more here.

Keywords: al2; chromatin state; chromatin; state switch ... See more keywords

Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.01.009

Abstract: Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on… read more here.

Keywords: complex generates; polycomb repressive; repressive complex; differentiation ... See more keywords

RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.

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recommendations! Published in 2017 at "Cell stem cell"

DOI: 10.1016/j.stem.2016.12.002

Abstract: RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA… read more here.

Keywords: ddx5 inhibits; inhibits reprogramming; ddx5; rybp ... See more keywords

USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-00301-4

Abstract: Despite much progress in the comprehension of the complex process of somatic cell reprogramming, many questions regarding the molecular mechanism of regulation remain to be answered. At present, the knowledge on the negative regulation of… read more here.

Keywords: negative regulator; cbx4 cbx6; usp26 functions; functions negative ... See more keywords

Targeted disruption of PRC1.1 complex enhances bone remodeling

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-59638-w

Abstract: Polycomb repressive complexes (PRCs) are pivotal epigenetic regulators that preserve cell identity by restricting transcription responses to sub-threshold extracellular signals. Their roles in osteoblast function and bone formation remain unclear. Here in aging osteoblasts, we… read more here.

Keywords: prc1; bone remodeling; prc1 complex; bone formation ... See more keywords

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-82189-1

Abstract: Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has been reported between SFKs and the mitotic spindle; however, the underlying mechanisms… read more here.

Keywords: tyrosine phosphorylation; kinastrin; kinastrin skap; prc1 ... See more keywords

RepID promotes metastatic potential in osteosarcoma through regulation of the PRC1-GATA6 axis

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recommendations! Published in 2025 at "Animal Cells and Systems"

DOI: 10.1080/19768354.2025.2598973

Abstract: ABSTRACT Osteosarcoma is the most common primary malignant bone tumor and is characterized by a high propensity for metastasis, most frequently to the lungs and lymph nodes. Despite extensive research, the key modulators and their… read more here.

Keywords: prc1; osteosarcoma; gata6; gata6 axis ... See more keywords

ATRT-07. PRC1/BMI1 ACTIVITY ALTERS CHROMATIN ACCESSIBILITY TO REGULATE DIFFERENTIATION IN ATYPICAL TERATOID RHABDOID TUMORS

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recommendations! Published in 2024 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noae064.007

Abstract: Abstract BACKGROUND SMARCB1 is a member of the SWI/SNF chromatin remodeling complex that is responsible for determining cellular pluripotency and lineage commitment. Atypical Teratoid Rhabdoid Tumor (ATRT) is a highly aggressive pediatric brain tumor and… read more here.

Keywords: prc1; differentiation; atypical teratoid; teratoid rhabdoid ... See more keywords