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Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202205573
Abstract: Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono-ubiquitination (H2AK119ub). BMI1 and RING1B are PRC1 core components and play critical roles in the development of various cancers.…
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Keywords:
bmi1 ring1b;
protein complex;
prc1;
degradation ... See more keywords
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Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23831
Abstract: BACKGROUND Circular RNA (circRNA) is considered an important molecular marker for the early diagnosis of tumors and a potential therapeutic target. Herein, we investigated the role and regulatory mechanism of circKDM1B in hepatocellular carcinoma (HCC).…
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Keywords:
hepatocellular carcinoma;
mir 1322;
hcc;
circkdm1b ... See more keywords
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Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.11.018
Abstract: Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 have also been suggested, it has remained unclear whether Ub-dependent and -independent functions…
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Keywords:
fate restriction;
repression;
prc1;
repression prc1 ... See more keywords
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Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.08.021
Abstract: Polycomb group proteins play essential roles in transcriptional gene repression during both animal and plant development. Polycomb repression complex 1 (PRC1) is one of the key functional modules in polycomb group silencing. It acts as…
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Keywords:
al2;
chromatin state;
chromatin;
state switch ... See more keywords
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Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.01.009
Abstract: Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on…
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Keywords:
complex generates;
polycomb repressive;
repressive complex;
differentiation ... See more keywords
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Published in 2017 at "Cell stem cell"
DOI: 10.1016/j.stem.2016.12.002
Abstract: RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA…
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Keywords:
ddx5 inhibits;
inhibits reprogramming;
ddx5;
rybp ... See more keywords
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Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00301-4
Abstract: Despite much progress in the comprehension of the complex process of somatic cell reprogramming, many questions regarding the molecular mechanism of regulation remain to be answered. At present, the knowledge on the negative regulation of…
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Keywords:
negative regulator;
cbx4 cbx6;
usp26 functions;
functions negative ... See more keywords
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1
Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82189-1
Abstract: Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has been reported between SFKs and the mitotic spindle; however, the underlying mechanisms…
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Keywords:
tyrosine phosphorylation;
kinastrin;
kinastrin skap;
prc1 ... See more keywords
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Published in 2019 at "BMC Genomics"
DOI: 10.1186/s12864-019-5905-9
Abstract: BackgroundPolycomb group (PcG) proteins play important roles in animal and plant development and stress response. Polycomb repressive complex 1 (PRC1) and PRC2 are the key epigenetic regulators of gene expression, and are involved in almost…
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Keywords:
evolution;
polycomb repressive;
associated factors;
prc1 ... See more keywords
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2
Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270572
Abstract: Cell-cycle dependent proteins are indispensible for the accurate division of cells, a group of proteins called Microtubule-associated proteins (MAPs) are important to cell division as it bind microtubules and participate with other co-factors to form…
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Keywords:
structure;
solution structure;
solution;
prc1 ... See more keywords
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Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010801
Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes lifelong infection in humans by establishing latency after primary infection. Latent infection is a prerequisite for both persistent infection and the development of KSHV-associated cancers.…
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Keywords:
infection;
lytic genes;
prc1 independent;
novo infection ... See more keywords