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   Articles with "prc1" as a keyword



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Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202205573

Abstract: Polycomb repressive complex 1 (PRC1) is an essential epigenetic regulator that mainly controls histone H2A Lys119 mono-ubiquitination (H2AK119ub). BMI1 and RING1B are PRC1 core components and play critical roles in the development of various cancers.… read more here.

Keywords: bmi1 ring1b; protein complex; prc1; degradation ... See more keywords
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CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.

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recommendations! Published in 2023 at "Environmental toxicology"

DOI: 10.1002/tox.23831

Abstract: BACKGROUND Circular RNA (circRNA) is considered an important molecular marker for the early diagnosis of tumors and a potential therapeutic target. Herein, we investigated the role and regulatory mechanism of circKDM1B in hepatocellular carcinoma (HCC).… read more here.

Keywords: hepatocellular carcinoma; mir 1322; hcc; circkdm1b ... See more keywords
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Ubiquitination-Independent Repression of PRC1 Targets during Neuronal Fate Restriction in the Developing Mouse Neocortex.

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recommendations! Published in 2018 at "Developmental cell"

DOI: 10.1016/j.devcel.2018.11.018

Abstract: Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 have also been suggested, it has remained unclear whether Ub-dependent and -independent functions… read more here.

Keywords: fate restriction; repression; prc1; repression prc1 ... See more keywords
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Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch.

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recommendations! Published in 2018 at "Journal of molecular biology"

DOI: 10.1016/j.jmb.2018.08.021

Abstract: Polycomb group proteins play essential roles in transcriptional gene repression during both animal and plant development. Polycomb repression complex 1 (PRC1) is one of the key functional modules in polycomb group silencing. It acts as… read more here.

Keywords: al2; chromatin state; chromatin; state switch ... See more keywords
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Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation.

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recommendations! Published in 2017 at "Molecular cell"

DOI: 10.1016/j.molcel.2017.01.009

Abstract: Master regulatory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during differentiation and development. Some PcG proteins covalently modify histones, which contributes to heritable repression. The role for other effects on… read more here.

Keywords: complex generates; polycomb repressive; repressive complex; differentiation ... See more keywords
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RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions.

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recommendations! Published in 2017 at "Cell stem cell"

DOI: 10.1016/j.stem.2016.12.002

Abstract: RNA-binding proteins (RBPs), in addition to their functions in cellular homeostasis, play important roles in lineage specification and maintaining cellular identity. Despite their diverse and essential functions, which touch on nearly all aspects of RNA… read more here.

Keywords: ddx5 inhibits; inhibits reprogramming; ddx5; rybp ... See more keywords
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USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-00301-4

Abstract: Despite much progress in the comprehension of the complex process of somatic cell reprogramming, many questions regarding the molecular mechanism of regulation remain to be answered. At present, the knowledge on the negative regulation of… read more here.

Keywords: negative regulator; cbx4 cbx6; usp26 functions; functions negative ... See more keywords

Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-82189-1

Abstract: Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has been reported between SFKs and the mitotic spindle; however, the underlying mechanisms… read more here.

Keywords: tyrosine phosphorylation; kinastrin; kinastrin skap; prc1 ... See more keywords
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Evolution and conservation of polycomb repressive complex 1 core components and putative associated factors in the green lineage

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recommendations! Published in 2019 at "BMC Genomics"

DOI: 10.1186/s12864-019-5905-9

Abstract: BackgroundPolycomb group (PcG) proteins play important roles in animal and plant development and stress response. Polycomb repressive complex 1 (PRC1) and PRC2 are the key epigenetic regulators of gene expression, and are involved in almost… read more here.

Keywords: evolution; polycomb repressive; associated factors; prc1 ... See more keywords
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Validation of the solution structure of dimerization domain of PRC1

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recommendations! Published in 2022 at "PLoS ONE"

DOI: 10.1371/journal.pone.0270572

Abstract: Cell-cycle dependent proteins are indispensible for the accurate division of cells, a group of proteins called Microtubule-associated proteins (MAPs) are important to cell division as it bind microtubules and participate with other co-factors to form… read more here.

Keywords: structure; solution structure; solution; prc1 ... See more keywords
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PRC1-independent binding and activity of RYBP on the KSHV genome during de novo infection

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recommendations! Published in 2022 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1010801

Abstract: Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes lifelong infection in humans by establishing latency after primary infection. Latent infection is a prerequisite for both persistent infection and the development of KSHV-associated cancers.… read more here.

Keywords: infection; lytic genes; prc1 independent; novo infection ... See more keywords