LAUSR

PRC2 loss drives MPNST metastasis and matrix remodeling

Sign Up to like & get
recommendations!
2 Published in 2022 at "JCI Insight"

DOI: 10.1172/jci.insight.157502

Abstract: The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a… read more here.

Keywords: prc2 loss; matrix remodeling; mpnst metastasis; loss ... See more keywords