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Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.03.011
Abstract: The polycomb repressive complex 2 (PRC2) is a chromatin-associated methyltransferase catalyzing mono-, di-, and trimethylation of lysine 27 on histone H3 (H3K27). This activity is required for normal organismal development and maintenance of gene expression…
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Keywords:
molecular mechanisms;
prc2 recruitment;
h3k27 methylation;
h3k27 ... See more keywords
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Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24894-z
Abstract: Polycomb repressive complexes-1 and -2 (PRC1 and 2) silence developmental genes in a spatiotemporal manner during embryogenesis. How Polycomb group (PcG) proteins orchestrate down-regulation of target genes upon differentiation, however, remains elusive. Here, by differentiating…
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Keywords:
target genes;
differentiation;
pcgf1 prc1;
prc2 recruitment ... See more keywords