Isolated anemia in patients with large granular lymphocytic leukemia (LGLL)
Sign Up to like & getrecommendations! Published in 2022 at "Blood Cancer Journal"
DOI: 10.1038/s41408-022-00632-6
Abstract: Patients with large granular lymphocytic leukemia (LGLL) frequently present with neutropenia. When present, anemia is usually accompanied by neutropenia and/or thrombocytopenia and isolated anemia is uncommon. We evaluated a cohort of 244 LGLL patients spanning… read more here.
Keywords: isolated anemia; non prca; prca; lgll ... See more keywords
Successful treatment of refractory pure red cell aplasia in major ABO-mismatched allogeneic hematopoietic stem cell transplant with single agent Ibrutinib
Sign Up to like & getrecommendations! Published in 2022 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-022-01590-0
Abstract: TO THE EDITOR: Allogeneic hematopoietic stem cell transplant (allo-HCT) is a potentially curative treatment for several malignant and nonmalignant hematological disorders. The basis of allo-HCT is the matching of human leukocyte antigen (HLA), which is… read more here.
Keywords: red cell; prca; treatment; cell ... See more keywords
Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01669-3
Abstract: Prostate cancer is the second most common solid tumour in men worldwide and it is also the most common cancer affecting men of African descent. Prostate cancer incidence and mortality vary across regions and populations.… read more here.
Keywords: cancer; risk; prca; screening management ... See more keywords
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00960-x
Abstract: MYC drives the tumorigenesis of human cancers, including prostate cancer (PrCa), thus deubiquitinase (DUB) that maintains high level of c-Myc oncoprotein is a rational therapeutic target. Several ubiquitin-specific protease (USP) family members of DUB have… read more here.
Keywords: prostatic tumorigenesis; otud6a; prca; myc ... See more keywords
Clonal hematopoiesis in adult pure red cell aplasia
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DOI: 10.1038/s41598-021-81890-5
Abstract: Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression and anemia relapse… read more here.
Keywords: red cell; clonal hematopoiesis; prca; pure red ... See more keywords
Comprehensive role of prostate‐specific antigen identified with proteomic analysis in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15634
Abstract: Current treatments including androgen deprivation fail to prevent prostate cancer (PrCa) from progressing to castration‐resistant PrCa (CRPC). Accumulating evidence highlights the relevance of prostate‐specific antigen (PSA) in the development and progression of PrCa. The underlying… read more here.
Keywords: prostate; psa; analysis; prca ... See more keywords
Abstract 4657: Docetaxel nanoformulation reverts drug resistance in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4657
Abstract: Objectives: Docetaxel (Dtx) is the primary choice for the treatment of castrate-resistant prostate cancer (PrCa). Besides its therapeutic benefits, many men with castrate-resistant PCa fail to respond to treatment due to Dtx resistance. There are… read more here.
Keywords: prca; mnp dtx; drug; dtx ... See more keywords
Recurrent STAT3 Mutations in the Lymphocytes of Pure Red Cell Aplasia without T-Cell Large Granular Lymphocytic Leukemia
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DOI: 10.1182/blood.v130.suppl_1.1181.1181
Abstract: Background: Activating somatic mutations of STAT3 are one of the most frequently recognized genetic alterations in T-cell lymphoma including T-cell large granular lymphocytic leukemia (T-LGLL). T-LGLL is associated with certain proportions of patients (pts) with… read more here.
Keywords: prca; stat3 mutations; cell; prca lgll ... See more keywords
Prognostic impact of tristetraprolin (TTP) and PTEN loss and assessment of associated immune infiltrates in localized prostate cancer (PrCa).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e16601
Abstract: e16601 Background: We previously showed that loss of PTEN by quantitative multiplex immunofluorescence (qIF) is associated with relapse after prostatectomy. Low expression of TTP, which modulates the NF-kB pathway and inflammation, is prognostic for lethal… read more here.
Keywords: tristetraprolin ttp; prca; impact tristetraprolin; loss ... See more keywords
Expanded Criteria Donor-Related Hyperkalemia and Postreperfusion Cardiac Arrest During Liver Transplantation: A Case Report and Literature Review
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Transplantation"
DOI: 10.12659/aot.909308
Abstract: Background Liver transplantation (LT) using extended criteria donor (ECD) grafts is frequently associated with a high flush fluid potassium concentration (FFK) and acute hyperkalemia after reperfusion, which puts patients at greater risk of postreperfusion cardiac… read more here.
Keywords: related hyperkalemia; case; reperfusion; hyperkalemia ... See more keywords
Identification of Candidate mRNA Isoforms for Prostate Cancer-Risk SNPs Utilizing Iso-eQTL and sQTL Methods
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012406
Abstract: Single nucleotide polymorphisms (SNPs) impacting the alternative splicing (AS) process (sQTLs) or isoform expression (iso-eQTL) are implicated as important cancer regulatory elements. To find the sQTL and iso-eQTL, we retrieved prostate cancer (PrCa) tissue RNA-seq… read more here.
Keywords: prca; iso eqtl; mrna isoforms; iso ... See more keywords