Epidemiologic sequential analysis of pure red blood cell aplasia and T-cell large granular lymphocyte leukemia in Korea
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Hematology"
DOI: 10.1007/s00277-025-06406-x
Abstract: Pure red cell aplasia (PRCA) is a rare hematologic syndrome characterized by anemia with marked reticulocytopenia and, in Asia, is often accompanied by T-cell large granular lymphocyte leukemia (T-LGL). Minimal research has been done on… read more here.
Keywords: pure red; cell large; cell; cell aplasia ... See more keywords
Isolated anemia in patients with large granular lymphocytic leukemia (LGLL)
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DOI: 10.1038/s41408-022-00632-6
Abstract: Patients with large granular lymphocytic leukemia (LGLL) frequently present with neutropenia. When present, anemia is usually accompanied by neutropenia and/or thrombocytopenia and isolated anemia is uncommon. We evaluated a cohort of 244 LGLL patients spanning… read more here.
Keywords: isolated anemia; non prca; prca; lgll ... See more keywords
Successful treatment of refractory pure red cell aplasia in major ABO-mismatched allogeneic hematopoietic stem cell transplant with single agent Ibrutinib
Sign Up to like & getrecommendations! Published in 2022 at "Bone Marrow Transplantation"
DOI: 10.1038/s41409-022-01590-0
Abstract: TO THE EDITOR: Allogeneic hematopoietic stem cell transplant (allo-HCT) is a potentially curative treatment for several malignant and nonmalignant hematological disorders. The basis of allo-HCT is the matching of human leukocyte antigen (HLA), which is… read more here.
Keywords: red cell; prca; treatment; cell ... See more keywords
Prostate cancer risk in men of differing genetic ancestry and approaches to disease screening and management in these groups.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of cancer"
DOI: 10.1038/s41416-021-01669-3
Abstract: Prostate cancer is the second most common solid tumour in men worldwide and it is also the most common cancer affecting men of African descent. Prostate cancer incidence and mortality vary across regions and populations.… read more here.
Keywords: cancer; risk; prca; screening management ... See more keywords
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00960-x
Abstract: MYC drives the tumorigenesis of human cancers, including prostate cancer (PrCa), thus deubiquitinase (DUB) that maintains high level of c-Myc oncoprotein is a rational therapeutic target. Several ubiquitin-specific protease (USP) family members of DUB have… read more here.
Keywords: prostatic tumorigenesis; otud6a; prca; myc ... See more keywords
Clonal hematopoiesis in adult pure red cell aplasia
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81890-5
Abstract: Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression and anemia relapse… read more here.
Keywords: red cell; clonal hematopoiesis; prca; pure red ... See more keywords
Comprehensive role of prostate‐specific antigen identified with proteomic analysis in prostate cancer
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15634
Abstract: Current treatments including androgen deprivation fail to prevent prostate cancer (PrCa) from progressing to castration‐resistant PrCa (CRPC). Accumulating evidence highlights the relevance of prostate‐specific antigen (PSA) in the development and progression of PrCa. The underlying… read more here.
Keywords: prostate; psa; analysis; prca ... See more keywords
Abstract 4657: Docetaxel nanoformulation reverts drug resistance in prostate cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4657
Abstract: Objectives: Docetaxel (Dtx) is the primary choice for the treatment of castrate-resistant prostate cancer (PrCa). Besides its therapeutic benefits, many men with castrate-resistant PCa fail to respond to treatment due to Dtx resistance. There are… read more here.
Keywords: prca; mnp dtx; drug; dtx ... See more keywords
Sirolimus Plus Roxadustat in Patients with Pure Red Cell Aplasia: Results from a Prospective Multi-Center Clinical Trial
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DOI: 10.1182/blood-2024-201926
Abstract: BACKGROUND Pure red cell aplasia (PRCA) is a rare disease and the treatment is still challenging. We investigated the safety and efficacy of sirolimus plus roxadustat in patients with acquired PRCA. METHODS Sirolimus was initiated… read more here.
Keywords: treatment; newly diagnosed; sirolimus plus; response ... See more keywords
Gene Mutation Profiles of Primary Pure Red Cell Aplasia and Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia
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DOI: 10.1182/blood-2024-202927
Abstract: Acquired pure red cell aplasia (PRCA) is a kind of rare bone marrow failure disease characterized by destruction of erythrocyte by the immune system. However, the gene mutation profile of acquired PRCA remains obscure. Herein,… read more here.
Keywords: pure red; cell aplasia; mutation; red cell ... See more keywords
Recurrent STAT3 Mutations in the Lymphocytes of Pure Red Cell Aplasia without T-Cell Large Granular Lymphocytic Leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.1181.1181
Abstract: Background: Activating somatic mutations of STAT3 are one of the most frequently recognized genetic alterations in T-cell lymphoma including T-cell large granular lymphocytic leukemia (T-LGLL). T-LGLL is associated with certain proportions of patients (pts) with… read more here.
Keywords: prca; stat3 mutations; cell; prca lgll ... See more keywords