Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300070
Abstract: PRDM16 (PR domain containing protein 16) serves as a dominant activator of brown and beige adipocyte. However, mechanisms underlying the regulation of PRDM16 expression are incompletely understood. A Prdm16 luciferase knockin reporter mouse model is generated, enabling high… read more here.
Keywords: prdm16; androgen receptor; beige adipocyte; expression ... See more keywords
Prdm3 and Prdm16 cooperatively maintain hematopoiesis and clonogenic potential.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental hematology"
DOI: 10.1016/j.exphem.2020.04.010
Abstract: Mds1-Evi1 (also known as Prdm3) and Prdm16 are two highly related zinc finger transcription factors that, within the hematopoietic system, are both expressed primarily in hematopoietic stem cells (HSCs). Our lab has previously shown that… read more here.
Keywords: mds1 evi1; prdm16; evi1 prdm16; knockout ... See more keywords
miR-1275 inhibits human omental adipose-derived stem cells differentiation towards the beige phenotype via PRDM16.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells and development"
DOI: 10.1089/scd.2022.0176
Abstract: Beige adipocytes have recently attracted attention for their potential as new therapeutic targets in the management of obesity and related metabolic disorders. MicroRNAs (miRNAs) have been reported as transcriptional regulators or biomarkers of brown and… read more here.
Keywords: prdm16; human omental; differentiation; stem cells ... See more keywords
PRDM16, negatively regulated by miR-372-3p, suppresses cell proliferation and invasion in prostate cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Andrologia"
DOI: 10.1111/and.14529
Abstract: Prostate cancer (PCa) is one of the most prevalent malignant tumours. The alternation of microRNAs (miRNAs) expression is associated with prostate cancer progression, whereas its way to influence progression of prostate cancer remains elusive. The… read more here.
Keywords: mir 372; prostate cancer; proliferation; prdm16 ... See more keywords
A cardiac-null mutation of Prdm16 causes hypotension in mice with cardiac hypertrophy via increased nitric oxide synthase 1
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267938
Abstract: Hypertension or hypotension prevails as a comorbidity in patients with heart failure (HF). Although blood pressure (BP) is an important factor in managing the mortality of HF, the molecular mechanisms of changes in BP have… read more here.
Keywords: hypotension; mice cardiac; prdm16; null mutation ... See more keywords
Impact of HOXB4 and PRDM16 Gene Expressions on Prognosis and Treatment Response in Acute Myeloid Leukemia Patients
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacogenomics and Personalized Medicine"
DOI: 10.2147/pgpm.s368640
Abstract: Introduction Acute myeloid leukemia (AML) is the most common type of leukemia among adults and is characterized by various genetic abnormalities. HOXB4 and PRDM16 are promising markers of AML. Our objective is to assess the… read more here.
Keywords: prdm16; hoxb4 prdm16; gene expressions; leukemia ... See more keywords
Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2021.360
Abstract: Environmental temperature serves as a major driver of adaptive changes in wild organisms. To discover the mechanisms underpinning cold tolerance in domestic animals, we sequenced the genomes of 28 cattle from warm and cold areas… read more here.
Keywords: prdm16; domestic cattle; tolerance domestic; tolerance ... See more keywords