Prdm6 controls heart development by regulating neural crest cell differentiation and migration
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DOI: 10.1172/jci.insight.156046
Abstract: The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identified Prdm6 as an epigenetic modifier that temporally and spatially regulates the expression of NCC… read more here.
Keywords: neural crest; migration; differentiation; prdm6 ... See more keywords
Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.163454
Abstract: Based upon our demonstration that the smooth muscle cell–selective (SMC-selective) putative methyltransferase, Prdm6, interacts with myocardin-related transcription factor-A, we examined Prdm6’s role in SMCs in vivo using cell type–specific knockout mouse models. Although SMC-specific depletion… read more here.
Keywords: cell; muscle cell; depletion; ductus arteriosus ... See more keywords