A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.28383
Abstract: PRDM9 binding localizes almost all meiotic recombination sites in humans and mice. However, most PRDM9-bound loci do not become recombination hotspots. To explore factors that affect binding and subsequent recombination outcomes, we mapped human PRDM9… read more here.
Keywords: prdm9 zinc; human prdm9; prdm9; recombination ... See more keywords
PRDM9 activity depends on HELLS and promotes local 5-hydroxymethylcytosine enrichment
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.57117
Abstract: Meiotic recombination starts with the formation of DNA double-strand breaks (DSBs) at specific genomic locations that correspond to PRDM9-binding sites. The molecular steps occurring from PRDM9 binding to DSB formation are unknown. Using proteomic approaches… read more here.
Keywords: hydroxymethylcytosine; enrichment; prdm9 binding; dsb activity ... See more keywords