Missing the Mark: PRDM9-Dependent Methylation Is Required for Meiotic DSB Targeting.
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DOI: 10.1016/j.molcel.2018.02.021
Abstract: PRDM9 determines the localization of meiotic recombination hotspots, which are associated with histone H3 methylation. It is not known whether PRDM9's methyltransferase activity is required or how some PRDM9 alleles can dominate the distribution of hotspots… read more here.
Keywords: methylation; missing mark; mark prdm9; prdm9 ... See more keywords