PRDX1 enhances cerebral ischemia-reperfusion injury through activation of TLR4-regulated inflammation and apoptosis.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.077
Abstract: Stroke is still a leading cause of death across the world. Despite various signals or molecules that contribute to the pathophysiological process have been investigated, the exact molecular mechanisms revealing stroke damage still remain to… read more here.
Keywords: cerebral ischemia; tlr4; injury; inflammation apoptosis ... See more keywords
PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108347
Abstract: Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA breaks (SSBs). The peroxiredoxin-PRDX1 is… read more here.
Keywords: cleavage events; dna repair; damage; prdx1 ... See more keywords
Loss of PRDX1 increases RAD51 Cys319 oxidation and decreases homologous recombination
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.159
Abstract: Peroxiredoxin 1 (PRDX1) is an oxidative stress protein sensor, which can coordinate cell signaling of its binding partners. Loss of Prdx1 function in mice has been shown to enhance susceptibility to various cancers, including breast… read more here.
Keywords: loss prdx1; oxidation; homologous recombination; prdx1 ... See more keywords
Comprehensive analysis of the expression levels and prognostic values of PRDX family genes in glioma
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2021.105256
Abstract: Gliomas are a histologically and molecularly heterogeneous group of neoplasms accounting for 80% of malignant primary brain tumors. Growing evidence suggests that production of reactive oxygen species (ROS) is linked to glioma pathogenesis, although it… read more here.
Keywords: analysis; expression; prdx4 prdx6; prdx1 ... See more keywords
Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Cancer"
DOI: 10.1038/s41416-018-0263-y
Abstract: ABSTRACTBackgroundOur previous work has shown peroxiredoxin-1 (PRDX1), one of major antioxidant enzymes, to be a biomarker in human breast cancer. Hereby, we further investigate the role of PRDX1, compared to its close homolog PRDX2, in… read more here.
Keywords: breast cancer; prooxidant agents; cancer; growth ... See more keywords
Inflammation-induced reactive nitrogen species cause proteasomal degradation of dimeric peroxiredoxin-1 in a mouse macrophage cell line
Sign Up to like & getrecommendations! Published in 2019 at "Free Radical Research"
DOI: 10.1080/10715762.2019.1637863
Abstract: Abstract Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme that, when secreted, can act as a proinflammatory signal. Here we studied the regulation of intracellular PRDX1 by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in the RAW 264.7… read more here.
Keywords: cell line; macrophage cell; peroxiredoxin; mouse macrophage ... See more keywords
SO025DCR2 ACCELERATES RENAL FIBROSIS AND TUBULAR CELL SENESCENCE BY PHOSPHORYLATING TYR 194 OF PRDX1 IN DIABETIC NEPHROPATHY
Sign Up to like & getrecommendations! Published in 2020 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaa139.so025
Abstract: Cell senescence of renal tubular epithelial cells (RTECs), which is involved in renal tubulointerstitial fibrosis (TIF), is a key event in the progression of diabetic nephropathy (DN). However, the underlying mechanism remains unclear. This study… read more here.
Keywords: dcr2; fibrosis; prdx1; cell senescence ... See more keywords
Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/2405135
Abstract: Background. Previous research has shown that peroxiredoxin 1 (Prdx1) is an important modulator of physiological and pathophysiological cardiovascular events. This study is aimed at investigating the role and underlying mechanism of Prdx1 in doxorubicin- (DOX-)… read more here.
Keywords: overexpression; induced cardiotoxicity; apoptosis; cardiotoxicity ... See more keywords
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-20-1023
Abstract: NK cells are susceptible to oxidative stress in the TME. Priming with IL15 upregulates the antioxidant enzyme PRDX1 and protects from oxidative stress. PD-L1–CAR NK cells overexpressing PRDX1 exhibit resistance to oxidative stress and improved… read more here.
Keywords: prdx1; stress; oxidative stress; hydrogen peroxide ... See more keywords
Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.21539
Abstract: Peroxiredoxin-1 (Prdx1), a member of the thioredoxin (Txn) system, is overexpressed and correlates with poor prognosis in pancreatic cancer patients and can suppress Kras signaling through redox-mediated inhibition of ERK and AKT in lung and… read more here.
Keywords: system; txn; expression; pancreatic neoplasia ... See more keywords
Decreased expression of peroxiredoxin1 inhibits proliferation, invasion, and metastasis of ovarian cancer cell
Sign Up to like & getrecommendations! Published in 2018 at "OncoTargets and therapy"
DOI: 10.2147/ott.s175009
Abstract: Aim The aim of this study was to explore the expression of peroxiredoxin1 (PRDX1) in epithelial ovarian cancer, analyze the relationship between PRDX1 and clinicopathologic parameters of patients with ovarian cancer, including their prognosis, and… read more here.
Keywords: expression; ovarian cancer; cancer cell; cancer ... See more keywords