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   Articles with "prdx1" as a keyword



PRDX1 enhances cerebral ischemia-reperfusion injury through activation of TLR4-regulated inflammation and apoptosis.

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recommendations! Published in 2019 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2019.08.077

Abstract: Stroke is still a leading cause of death across the world. Despite various signals or molecules that contribute to the pathophysiological process have been investigated, the exact molecular mechanisms revealing stroke damage still remain to… read more here.

Keywords: cerebral ischemia; tlr4; injury; inflammation apoptosis ... See more keywords

PRDX1 Counteracts Catastrophic Telomeric Cleavage Events That Are Triggered by DNA Repair Activities Post Oxidative Damage.

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recommendations! Published in 2020 at "Cell reports"

DOI: 10.1016/j.celrep.2020.108347

Abstract: Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA breaks (SSBs). The peroxiredoxin-PRDX1 is… read more here.

Keywords: cleavage events; dna repair; damage; prdx1 ... See more keywords

Loss of PRDX1 increases RAD51 Cys319 oxidation and decreases homologous recombination

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.159

Abstract: Peroxiredoxin 1 (PRDX1) is an oxidative stress protein sensor, which can coordinate cell signaling of its binding partners. Loss of Prdx1 function in mice has been shown to enhance susceptibility to various cancers, including breast… read more here.

Keywords: loss prdx1; oxidation; homologous recombination; prdx1 ... See more keywords

Comprehensive analysis of the expression levels and prognostic values of PRDX family genes in glioma

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recommendations! Published in 2022 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2021.105256

Abstract: Gliomas are a histologically and molecularly heterogeneous group of neoplasms accounting for 80% of malignant primary brain tumors. Growing evidence suggests that production of reactive oxygen species (ROS) is linked to glioma pathogenesis, although it… read more here.

Keywords: analysis; expression; prdx4 prdx6; prdx1 ... See more keywords

Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitises these cells to prooxidant agents

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recommendations! Published in 2018 at "British Journal of Cancer"

DOI: 10.1038/s41416-018-0263-y

Abstract: ABSTRACTBackgroundOur previous work has shown peroxiredoxin-1 (PRDX1), one of major antioxidant enzymes, to be a biomarker in human breast cancer. Hereby, we further investigate the role of PRDX1, compared to its close homolog PRDX2, in… read more here.

Keywords: breast cancer; prooxidant agents; cancer; growth ... See more keywords

Inflammation-induced reactive nitrogen species cause proteasomal degradation of dimeric peroxiredoxin-1 in a mouse macrophage cell line

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recommendations! Published in 2019 at "Free Radical Research"

DOI: 10.1080/10715762.2019.1637863

Abstract: Abstract Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme that, when secreted, can act as a proinflammatory signal. Here we studied the regulation of intracellular PRDX1 by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in the RAW 264.7… read more here.

Keywords: cell line; macrophage cell; peroxiredoxin; mouse macrophage ... See more keywords

SO025DCR2 ACCELERATES RENAL FIBROSIS AND TUBULAR CELL SENESCENCE BY PHOSPHORYLATING TYR 194 OF PRDX1 IN DIABETIC NEPHROPATHY

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recommendations! Published in 2020 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaa139.so025

Abstract: Cell senescence of renal tubular epithelial cells (RTECs), which is involved in renal tubulointerstitial fibrosis (TIF), is a key event in the progression of diabetic nephropathy (DN). However, the underlying mechanism remains unclear. This study… read more here.

Keywords: dcr2; fibrosis; prdx1; cell senescence ... See more keywords

Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis

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recommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2020/2405135

Abstract: Background. Previous research has shown that peroxiredoxin 1 (Prdx1) is an important modulator of physiological and pathophysiological cardiovascular events. This study is aimed at investigating the role and underlying mechanism of Prdx1 in doxorubicin- (DOX-)… read more here.

Keywords: overexpression; induced cardiotoxicity; apoptosis; cardiotoxicity ... See more keywords

PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress

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recommendations! Published in 2021 at "Cancer Immunology Research"

DOI: 10.1158/2326-6066.cir-20-1023

Abstract: NK cells are susceptible to oxidative stress in the TME. Priming with IL15 upregulates the antioxidant enzyme PRDX1 and protects from oxidative stress. PD-L1–CAR NK cells overexpressing PRDX1 exhibit resistance to oxidative stress and improved… read more here.

Keywords: prdx1; stress; oxidative stress; hydrogen peroxide ... See more keywords

Thioredoxin system-mediated regulation of mutant Kras associated pancreatic neoplasia and cancer

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.21539

Abstract: Peroxiredoxin-1 (Prdx1), a member of the thioredoxin (Txn) system, is overexpressed and correlates with poor prognosis in pancreatic cancer patients and can suppress Kras signaling through redox-mediated inhibition of ERK and AKT in lung and… read more here.

Keywords: system; txn; expression; pancreatic neoplasia ... See more keywords

PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling

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recommendations! Published in 2025 at "Oncotarget"

DOI: 10.18632/oncotarget.28720

Abstract: Redox regulation and DNA repair coordination are essential for genomic stability. Peroxiredoxin 1 (PRDX1) is a thiol-dependent peroxidase and a chaperone that protects proteins from excessive oxidation. ATM kinase (Ataxia-Telangiectasia Mutated) and the MRN (MRE11-RAD50-NBS1)… read more here.

Keywords: dna damage; prdx1; deleted cells; prdx1 deleted ... See more keywords