Peroxiredoxin 4 suppresses anoikis and augments growth and metastasis of hepatocellular carcinoma cells through the β-catenin/ID2 pathway
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Oncology"
DOI: 10.1007/s13402-019-00460-0
Abstract: Peroxiredoxin 4 (PRDX4) has been reported to play a dual role in the progression of hepatocellular carcinoma (HCC). As yet, however, the underlying molecular mechanism has not been fully elucidated. We examined the effects of… read more here.
Keywords: prdx4; hcc cells; anchorage independent; metastasis ... See more keywords
Oxidation state of peroxiredoxin 4 in lungs from patients with pulmonary fibrosis and mouse models of fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.014
Abstract: Rationale Every year 34,000 people in the United States are diagnosed with Idiopathic Pulmonary Fibrosis (IPF). The average survival time for these patients is only 3-5 years after diagnosis. Recently we have shown that the… read more here.
Keywords: mouse models; fibrosis; prdx4; peroxiredoxin ... See more keywords
Peroxiredoxin 4 as a switch regulating PTEN/AKT axis in alveolar macrophages activation
Sign Up to like & getrecommendations! Published in 2025 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-025-02454-x
Abstract: Phosphatase and tensin homolog (PTEN) is a critical inhibitor of the PI3K/AKT signaling pathway, yet its direct upstream regulators remain poorly defined. In this study, we investigated the role of peroxiredoxin 4 (PRDX4) in alveolar… read more here.
Keywords: fibrosis; switch regulating; peroxiredoxin; alveolar macrophages ... See more keywords
Suppression of PRDX4 inhibits cell proliferation and invasion of ectopic endometrial stromal cells in endometriosis
Sign Up to like & getrecommendations! Published in 2020 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2020.1768369
Abstract: Abstract Oxidative stress (OS) has been proposed to play a role in the development of EMs. Peroxiredoxins are a family of antioxidant proteins that exhibit peroxidase activity in a thioredoxin-dependent manner, protecting cells against OS.… read more here.
Keywords: invasion; prdx4; stromal cells; endometrial stromal ... See more keywords
Abstract A022: Disrupting redox homeostasis initiates anti-tumor immune responses in pancreatic cancer
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DOI: 10.1158/1538-7445.tumbody-a022
Abstract: Although immune therapy has made impressive progress in cancer treatment, pancreatic ductal adenocarcinoma (PDAC) remains an exception, likely due to its immunosuppressive tumor microenvironment that prevents immune responses against the tumor. Our current work aims… read more here.
Keywords: cancer; disrupting redox; immune responses; radiation ... See more keywords
Validation of the interaction between PRDX4 and TXNDC5 in gastric cancer and the significance of the PRDX4 gene in gastric cancer based on a data mining analysis
Sign Up to like & getrecommendations! Published in 2024 at "Translational Cancer Research"
DOI: 10.21037/tcr-23-904
Abstract: Background We successfully screened the important interacting protein peroxiredoxin 4 (PRDX4) of thioredoxin domain-containing protein 5 (TXNDC5) in gastric cancer. However, its specific molecular mechanism in gastric cancer remains unclear. This study aimed to verify… read more here.
Keywords: cancer; txndc5; gastric cancer; protein ... See more keywords