The role of TLR4/NF-κB signaling in the radioprotective effects of exogenous Prdx6.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108830
Abstract: Peroxiredoxin 6 (Prdx6) is a bifunctional enzyme with multi-substrate peroxidase and phospholipase activities that is involved in cell redox homeostasis and regulates intracellular processes. Previously, recombinant Prdx6 was shown to exert a radioprotective effect during… read more here.
Keywords: role tlr4; radioprotective effect; prdx6; tlr4 ... See more keywords
Critical Role of Peroxiredoxin 6 in the Repair of Peroxidized Lung Membrane Phospholipids
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.055
Abstract: Peroxidation of membrane lipids represents a severe threat to cellular integrity and its repair is crucial to prevent cell death. Peroxiredoxin 6 (Prdx6), a protein with both GSH peroxidase and phospholipase A2 (PLA2) activities, plays… read more here.
Keywords: lungs pmvec; repair peroxidized; role; prdx6 ... See more keywords
Peroxiredoxin 6 phospholipid hydroperoxidase activity in the repair of peroxidized cell membranes
Sign Up to like & getrecommendations! Published in 2018 at "Redox Biology"
DOI: 10.1016/j.redox.2017.08.008
Abstract: Although lipid peroxidation associated with oxidative stress can result in cellular death, sub-lethal lipid peroxidation can gradually resolve with return to the pre-exposure state. We have shown that resolution of lipid peroxidation is greatly delayed… read more here.
Keywords: recovery; repair peroxidized; lipid peroxidation; peroxidation ... See more keywords
Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149-5p and increasing PRDX6 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Reproductive biology"
DOI: 10.1016/j.repbio.2022.100619
Abstract: Cervical cancer (CC) is a common tumor in the female reproductive tract. Circular RNA hsa_circ_0011385 has been reported to be up-regulated in CC tissues. Nevertheless, the role and regulatory mechanism of hsa_circ_0011385 in CC are… read more here.
Keywords: circ 0011385; hsa circ; prdx6; mir 149 ... See more keywords
Expression of PRDX6 Correlates with Migration and Invasiveness of Colorectal Cancer Cells
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000495934
Abstract: Background/Aims: Colorectal cancer (CRC) is the third most common type of cancer and the second leading cause of cancer-related deaths worldwide. PRDXs are antioxidant enzymes that play an important role in cell differentiation, proliferation and… read more here.
Keywords: prdx6; migration invasiveness; colorectal cancer; crc ... See more keywords
Integrative analysis the characterization of peroxiredoxins in pan-cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02064-x
Abstract: Background Peroxiredoxins (PRDXs) are an antioxidant enzymes protein family involved in several biological functions such as differentiation, cell growth. In addition, previous studies report that PRDXs play critical roles in the occurrence and development of… read more here.
Keywords: pan cancer; analysis; expression; prdx6 ... See more keywords
PRDX6 Overexpression Promotes Proliferation, Invasion, and Migration of A549 Cells in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Management and Research"
DOI: 10.2147/cmar.s284195
Abstract: Purpose Peroxiredoxin-6 (PRDX6) is frequently found in various cancers. However, its expression and relevance to proliferation, invasion, and migration in human non-small-cell lung cancer (NSCLC) remain unclear. This study investigated the role and novel mechanism… read more here.
Keywords: prdx6; overexpression; invasion; a549 cells ... See more keywords
2123-P: Peroxiredoxin6 Is a Novel Promoter of Pancreatic Beta-Cell Survival
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-2123-p
Abstract: Background: Diabetes is a multifactorial disease with low levels of inflammation and loss of functional pancreatic β-cell mass. Pancreatic β-cells have a reduced antioxidant capacity with an increased vulnerability to oxidative stress. Pro-inflammatory cytokines increasing… read more here.
Keywords: prdx6; none; beta cell; pancreatic beta ... See more keywords
Peroxiredoxin 6 Modulates Insulin Secretion and Beta Cell Death via a Mitochondrial Dynamic Network
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.842575
Abstract: In pancreatic beta cells, mitochondrial metabolism controls glucose-stimulated insulin secretion (GSIS) by ATP production, redox signaling, and calcium (Ca2+) handling. Previously, we demonstrated that knockout mice for peroxiredoxin 6 (Prdx6-/- ), an antioxidant enzyme with… read more here.
Keywords: cell; beta; prdx6; gsis ... See more keywords
Peroxiredoxin 6 Peroxidase and Ca2+-Independent Phospholipase A2 Activities Are Essential to Support Male-Mouse Fertility
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020226
Abstract: Human infertility is an important health problem that affects one in six couples worldwide. Half of these cases are due to male infertility. Oxidative stress is a common culprit of male infertility, promoting lipid peroxidation… read more here.
Keywords: male; mouse fertility; prdx6; peroxidase ... See more keywords
The Role of Peroxiredoxin 6 in Cell Signaling
Sign Up to like & getrecommendations! Published in 2018 at "Antioxidants"
DOI: 10.3390/antiox7120172
Abstract: Peroxiredoxin 6 (Prdx6, 1-cys peroxiredoxin) is a unique member of the peroxiredoxin family that, in contrast to other mammalian peroxiredoxins, lacks a resolving cysteine and uses glutathione and π glutathione S-transferase to complete its catalytic… read more here.
Keywords: peroxiredoxin cell; peroxiredoxin; cell signaling; role peroxiredoxin ... See more keywords