Abstract 93: Transcriptional control of glucocorticoid responses in leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-93
Abstract: Glucocorticoids (GCs) are central to all major therapy regimens for pre-B cell-derived acute lymphoblastic leukemia (ALL), but have no activity in myeloid leukemia. Such divergent responses represent an empirically established clinical standard; however, neither the… read more here.
Keywords: pre; pax5 ikzf1; cell; patient derived ... See more keywords
Spi-C and PU.1 Counterregulate Rag1 and Igκ Transcription to Effect Vκ-Jκ Recombination in Small Pre-B Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of immunology"
DOI: 10.4049/jimmunol.2300122
Abstract: B cell development requires the ordered rearrangement of Ig genes encoding H and L chain proteins that assemble into BCRs or Abs capable of recognizing specific Ags. Igκ rearrangement is promoted by chromatin accessibility and… read more here.
Keywords: small pre; transcription; pre cells; rag1 ... See more keywords