Wild-Type α-Synuclein and Variants Occur in Different Disordered Dimers and Pre-Fibrillar Conformations in Early Stage of Aggregation
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DOI: 10.3389/fmolb.2022.910104
Abstract: α-Synuclein is a 140 amino-acid intrinsically disordered protein mainly found in the brain. Toxic α-synuclein aggregates are the molecular hallmarks of Parkinson’s disease. In vitro studies showed that α-synuclein aggregates in oligomeric structures of several… read more here.
Keywords: pre fibrillar; stage aggregation; synuclein; early stage ... See more keywords