A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein
Sign Up to like & getrecommendations! Published in 2017 at "Nature microbiology"
DOI: 10.1038/nmicrobiol.2016.271
Abstract: Respiratory syncytial virus (RSV) remains a major human pathogen, infecting the majority of infants before age two and causing re-infection throughout life. Despite decades of RSV research, there is no licensed RSV vaccine. Most candidate… read more here.
Keywords: protein; respiratory syncytial; syncytial virus; site ... See more keywords
Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.979641
Abstract: We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters. Intranasal administration of BV-AdCoV-1 elicited strong humoral and… read more here.
Keywords: pre fusion; syrian hamsters; infection; adcov ... See more keywords
Structural Transition and Antibody Binding of EBOV GP and ZIKV E Proteins from Pre-Fusion to Fusion-Initiation State
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DOI: 10.3390/biom8020025
Abstract: Membrane fusion proteins are responsible for viral entry into host cells—a crucial first step in viral infection. These proteins undergo large conformational changes from pre-fusion to fusion-initiation structures, and, despite differences in viral genomes and… read more here.
Keywords: state; fusion initiation; fusion fusion; fusion ... See more keywords
Real-Time Analysis of Individual Ebola Virus Glycoproteins Reveals Pre-Fusion, Entry-Relevant Conformational Dynamics
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12010103
Abstract: The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion membrane with the membrane of susceptible target cells during infection. While proteolytic cleavage of GP by endosomal cathepsins and binding of the… read more here.
Keywords: fusion; entry; ebola virus; pre fusion ... See more keywords