Pre‐implantation genetic testing: Past, present, future
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12352
Abstract: Pre‐implantation genetic testing (PGT) has been performed worldwide since it was first used by Handyside et al in the United Kingdom to sex embryos in 1990. Until about 2010, cleavage stage embryo biopsy and fluorescent… read more here.
Keywords: genetic testing; pre implantation; testing past; implantation genetic ... See more keywords
Artificial intelligence applications for pre-implantation kidney biopsy pathology practice: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nephrology"
DOI: 10.1007/s40620-022-01327-8
Abstract: Transplant nephropathology is a highly specialized field of pathology comprising both the evaluation of organ donor biopsy for organ allocation and post-transplant graft biopsy for assessment of rejection or graft damage. The introduction of digital… read more here.
Keywords: pre implantation; kidney biopsy; biopsy; pathology ... See more keywords
Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.111
Abstract: Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation. Although genomic and transcriptomic studies have enriched our understanding of the genetic… read more here.
Keywords: protein expression; development; embryos; pre implantation ... See more keywords
PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2016.12.010
Abstract: Summary In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously, fluctuating between a PDGFRα+… read more here.
Keywords: cell; pre implantation; primitive endoderm; pre ... See more keywords
An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08244-0
Abstract: Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells,… read more here.
Keywords: pre implantation; accessibility transcriptome; accessibility; human pre ... See more keywords
Non-invasive pre-implantation genetic testing of human embryos: an emerging concept
Sign Up to like & getrecommendations! Published in 2018 at "Human Reproduction"
DOI: 10.1093/humrep/dey314
Abstract: The accurate genetic screening of pre-implantation embryos currently entails the use of technically challenging and biologically invasive biopsies of the human embryos. Investigating a more conservative sampling approach has emerged as a timely and desired… read more here.
Keywords: genetic testing; human embryos; pre implantation; implantation genetic ... See more keywords
A sister of NANOG regulates genes expressed in pre-implantation human development
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170027
Abstract: The NANOG homeobox gene plays a pivotal role in self-renewal and maintenance of pluripotency in human, mouse and other vertebrate embryonic stem cells, and in pluripotent cells of the blastocyst inner cell mass. There is… read more here.
Keywords: nanog; pre implantation; expressed pre; gene ... See more keywords
A systematic review exploring the patient decision‐making factors and attitudes towards pre‐implantation genetic testing for aneuploidy and gender selection
Sign Up to like & getrecommendations! Published in 2020 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.13973
Abstract: Pre‐implantation genetic testing for aneuploidy (PGT‐A) is in high demand worldwide, with ongoing debate among medical societies as to which patient groups it should be offered. The psychological aspects for patients regarding its use, lag… read more here.
Keywords: genetic testing; pre implantation; implantation genetic; testing aneuploidy ... See more keywords
Requirement of the 3′-UTR-dependent suppression of DAZL in oocytes for pre-implantation mouse development
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007436
Abstract: Functional oocytes are produced through complex molecular and cellular processes. In particular, the contribution of post-transcriptional gene regulation mediated by RNA-binding proteins (RBPs) is crucial for controlling proper gene expression during this process. DAZL (deleted… read more here.
Keywords: dazl; development; suppression dazl; pre implantation ... See more keywords
ChromInst: A single cell sequencing technique to accomplish pre-implantation comprehensive chromosomal screening overnight
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0251971
Abstract: Next Generation Sequencing (NGS) is a powerful tool getting into the field of clinical examination. Its preliminary application in pre-implantation comprehensive chromosomal screening (PCCS) of assisted reproduction (test-tube baby) has shown encouraging outcomes that improves… read more here.
Keywords: single cell; chrominst; pre implantation; implantation comprehensive ... See more keywords
GM-CSF perturbs cell identity in mouse pre-implantation embryos
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263793
Abstract: Growth factors became attractive candidates for medium supplementation to further improve the quality of embryo culture and to mimic in vivo nutrition. Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine influencing the maternal-fetal interface and… read more here.
Keywords: cell; csf; pre implantation; mouse ... See more keywords