Pre‐implantation genetic testing: Past, present, future
Sign Up to like & getrecommendations! Published in 2021 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12352
Abstract: Pre‐implantation genetic testing (PGT) has been performed worldwide since it was first used by Handyside et al in the United Kingdom to sex embryos in 1990. Until about 2010, cleavage stage embryo biopsy and fluorescent… read more here.
Keywords: genetic testing; pre implantation; testing past; implantation genetic ... See more keywords
Artificial intelligence applications for pre-implantation kidney biopsy pathology practice: a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Nephrology"
DOI: 10.1007/s40620-022-01327-8
Abstract: Transplant nephropathology is a highly specialized field of pathology comprising both the evaluation of organ donor biopsy for organ allocation and post-transplant graft biopsy for assessment of rejection or graft damage. The introduction of digital… read more here.
Keywords: pre implantation; kidney biopsy; biopsy; pathology ... See more keywords
Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.11.111
Abstract: Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation. Although genomic and transcriptomic studies have enriched our understanding of the genetic… read more here.
Keywords: protein expression; development; embryos; pre implantation ... See more keywords
PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2016.12.010
Abstract: Summary In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneously, fluctuating between a PDGFRα+… read more here.
Keywords: cell; pre implantation; primitive endoderm; pre ... See more keywords
An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08244-0
Abstract: Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells,… read more here.
Keywords: pre implantation; accessibility transcriptome; accessibility; human pre ... See more keywords
Nucleosome organization of mouse embryos during pre-implantation development
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-05642-5
Abstract: Sexual reproduction begins with sperm–oocyte fusion to form a zygote, where chromatin undergoes dramatic reorganization to establish totipotency. Although nucleosomes- the basic units of eukaryotic chromatin and key epigenetic regulators- are extensively remodeled during early… read more here.
Keywords: nucleosome organization; pre implantation; organization mouse; embryos pre ... See more keywords
O-196 Men who fathered embryos with poor pre-implantation development rates exhibit an increased frequency of sperm with high DNA accessibility
Sign Up to like & getrecommendations! Published in 2024 at "Human Reproduction"
DOI: 10.1093/humrep/deae108.229
Abstract: Do differing levels of DNA accessibility in sperm affect the ability of embryos generated by ART to undergo pre-implantation development? Individuals whose sperm generated embryos that failed to efficiently form blastocysts tend to have more… read more here.
Keywords: pre implantation; dna accessibility; accessibility; development ... See more keywords
P-561 Role of Parental Karyotyping test and Pre-Implantation Genetic Testing (PGT) in management of Recurrent Pregnancy Loss in assisted reproduction clinics?
Sign Up to like & getrecommendations! Published in 2025 at "Human Reproduction"
DOI: 10.1093/humrep/deaf097.867
Abstract: Is there a role for parental karyotyping(KT) test and Pre-Implantation-Genetic-Testing(PGT) in women with Recurrent Pregnancy Loss(RPL)? Can this help combat miscarriage in assisted reproduction cycles(ART)? KT test is mandatory for every woman with RPL. PGT… read more here.
Keywords: pre implantation; history; role; pgt ... See more keywords
Non-invasive pre-implantation genetic testing of human embryos: an emerging concept
Sign Up to like & getrecommendations! Published in 2018 at "Human Reproduction"
DOI: 10.1093/humrep/dey314
Abstract: The accurate genetic screening of pre-implantation embryos currently entails the use of technically challenging and biologically invasive biopsies of the human embryos. Investigating a more conservative sampling approach has emerged as a timely and desired… read more here.
Keywords: genetic testing; human embryos; pre implantation; implantation genetic ... See more keywords
Transcript profiling and gene regulation of the human pre-implantation embryo: parental effects and impact of ARTs.
Sign Up to like & getrecommendations! Published in 2025 at "Human reproduction update"
DOI: 10.1093/humupd/dmaf022
Abstract: BACKGROUND Infertility is a growing global challenge, with ARTs significantly improving birth rates for infertile couples. However, ART conceptions are associated with a higher risk of negative obstetrical and perinatal outcomes, with potential long-term effects… read more here.
Keywords: pre implantation; culture; implantation; gene ... See more keywords
A sister of NANOG regulates genes expressed in pre-implantation human development
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.170027
Abstract: The NANOG homeobox gene plays a pivotal role in self-renewal and maintenance of pluripotency in human, mouse and other vertebrate embryonic stem cells, and in pluripotent cells of the blastocyst inner cell mass. There is… read more here.
Keywords: nanog; pre implantation; expressed pre; gene ... See more keywords