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   Articles with "pre let" as a keyword



Kinetic and Mechanistic Studies of the Terminal Uridylyltransferase, Zcchc11 (TUT4).

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recommendations! Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00146

Abstract: Zcchc11 (TUT4, TENT3A, Z11) is a nucleotidyltransferase that catalyzes the 3'-polyuridylation of RNA. Our interest in this enzyme stems from its role in blocking the biogenesis of let-7, a family of microRNAs whose members act… read more here.

Keywords: z11; zcchc11 tut4; kinetic mechanistic; pre let ... See more keywords

Molecular Dynamics Simulations for Deciphering the Structural Basis of Recognition of Pre-let-7 miRNAs by LIN28.

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recommendations! Published in 2017 at "Biochemistry"

DOI: 10.1021/acs.biochem.6b00837

Abstract: LIN28 protein inhibits biogenesis of miRNAs belonging to the let-7 family by binding to precursor forms of miRNAs. Overexpression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells.… read more here.

Keywords: let mirnas; molecular dynamics; pre let; recognition ... See more keywords
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Let-7c regulated epithelial-mesenchymal transition leads to osimertinib resistance in NSCLC cells with EGFR T790M mutations

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-67908-4

Abstract: Epidermal growth factor receptor- tyrosine kinase inhibitors (EGFR-TKIs) have shown promise against non-small cell lung cancers (NSCLCs) in clinics but the utility is often short-lived because of T790M mutations in EGFR that help evade TKIs’… read more here.

Keywords: t790m mutations; pre let; wnt1 tcf; osimertinib resistance ... See more keywords

CMV Reactivation Pre and Post Letermovir Prophylaxis, a Single Centre Review of Clinical Outcomes and Resource Utilization

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recommendations! Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-193967

Abstract: Introduction Prospective, randomized trials have demonstrated reduction in the incidence of clinically significant CMV infections (csCMVi) with use of letermovir prophylaxis (LP) in allogeneic hematopoietic stem cell transplant (alloHSCT). Publicly funded LP became available at… read more here.

Keywords: post let; cmv; post; pre let ... See more keywords

Function and Regulation of Human Terminal Uridylyltransferases

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recommendations! Published in 2018 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2018.00538

Abstract: RNA uridylylation plays a pivotal role in the biogenesis and metabolism of functional RNAs, and regulates cellular gene expression. RNA uridylylation is catalyzed by a subset of proteins from the non-canonical terminal nucleotidyltransferase family. In… read more here.

Keywords: pre let; regulation human; oligo uridylylation; uridylylation ... See more keywords