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Kinetic and Mechanistic Studies of the Terminal Uridylyltransferase, Zcchc11 (TUT4).

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1 Published in 2022 at "Biochemistry"

DOI: 10.1021/acs.biochem.2c00146

Abstract: Zcchc11 (TUT4, TENT3A, Z11) is a nucleotidyltransferase that catalyzes the 3'-polyuridylation of RNA. Our interest in this enzyme stems from its role in blocking the biogenesis of let-7, a family of microRNAs whose members act… read more here.

Keywords: z11; zcchc11 tut4; kinetic mechanistic; pre let ... See more keywords

Molecular Dynamics Simulations for Deciphering the Structural Basis of Recognition of Pre-let-7 miRNAs by LIN28.

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0 Published in 2017 at "Biochemistry"

DOI: 10.1021/acs.biochem.6b00837

Abstract: LIN28 protein inhibits biogenesis of miRNAs belonging to the let-7 family by binding to precursor forms of miRNAs. Overexpression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells.… read more here.

Keywords: let mirnas; molecular dynamics; pre let; recognition ... See more keywords

Let-7c regulated epithelial-mesenchymal transition leads to osimertinib resistance in NSCLC cells with EGFR T790M mutations

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0 Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-67908-4

Abstract: Epidermal growth factor receptor- tyrosine kinase inhibitors (EGFR-TKIs) have shown promise against non-small cell lung cancers (NSCLCs) in clinics but the utility is often short-lived because of T790M mutations in EGFR that help evade TKIs’… read more here.

Keywords: t790m mutations; pre let; wnt1 tcf; osimertinib resistance ... See more keywords

Function and Regulation of Human Terminal Uridylyltransferases

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0 Published in 2018 at "Frontiers in Genetics"

DOI: 10.3389/fgene.2018.00538

Abstract: RNA uridylylation plays a pivotal role in the biogenesis and metabolism of functional RNAs, and regulates cellular gene expression. RNA uridylylation is catalyzed by a subset of proteins from the non-canonical terminal nucleotidyltransferase family. In… read more here.

Keywords: pre let; regulation human; oligo uridylylation; uridylylation ... See more keywords