Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
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DOI: 10.1038/s41586-018-0125-z
Abstract: Somatic mutations in tet methylcytosinedioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies1–7. In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with… read more here.
Keywords: pre leukaemic; tet2; pmp; microbial signals ... See more keywords