Trajectories from single-cells to PAX5-driven leukemia reveal PAX5-MYC interplay in vivo
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02626-2
Abstract: PAX5 acts as a master regulator of B-cell proliferation and differentiation. Its germline and somatic deregulation have both been implicated in the development of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). However, the process how reduced… read more here.
Keywords: bcp; pax5; trajectories single; pre leukemic ... See more keywords
Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state
Sign Up to like & getrecommendations! Published in 2025 at "Leukemia"
DOI: 10.1038/s41375-025-02665-9
Abstract: Infant Acute Lymphoblastic Leukemia (ALL) driven by the KMT2A::AFF1 onco-fusion is an aggressive, poor prognosis disease with few co-operative mutations. The fusion originates in utero, yet the embryonic initiating steps of disease development remain poorly… read more here.
Keywords: kmt2a aff1; pre; pre leukemic; fusion ... See more keywords
Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03009-4
Abstract: Early diagnosis of acute myeloid leukemia (AML) in the pre-leukemic stage remains a clinical challenge, as pre-leukemic patients show no symptoms, lacking any known morphological or numerical abnormalities in blood cells. Here, we demonstrate that… read more here.
Keywords: myeloid leukemia; platelets pre; acute myeloid; pre leukemic ... See more keywords
Prodromal / Pre-Leukemic Acute Leukemia of B-Lymphoblasts in 7 Adult Patients
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-143455
Abstract: Background: Prodromal/pre-leukemic acute leukemia is rare, mostly described in childhood B-lymphoblastic leukemia (B-ALL), with its initial presentation confused with aplastic anemia (AA). Findings reported in pediatric prodromal/pre-leukemic B-ALL include female preponderance, bone marrow (BM) fibrosis… read more here.
Keywords: acute leukemia; prodromal pre; pre leukemic;
Pre-malignant extracellular matrix drives leukemia transformation through reprogramming of pre-leukemic stem cells
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood-2025-3187
Abstract: Acute myeloid leukemia (AML) often arises from myelodysplasia (MDS), a pre-leukemic condition characterized by dysplasia and ineffective hematopoiesis. Despite extensive genetic and epigenetic profiling of AML, pathogenic mechanisms of disease development from pre-leukemic states remain… read more here.
Keywords: pre malignant; pre leukemic; stem; cell ... See more keywords
Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.280404
Abstract: The immune receptor TREM1 (Triggering receptor expressed on myeloid cells 1) is a master regulator of inflammatory response. Compelling evidence suggests important pathological roles for TREM1 in various types of solid tumors. However, the role… read more here.
Keywords: hsc lsc; dna damage; pre leukemic; trem1 ... See more keywords
Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsuficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.279437
Abstract: Mono-Allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) affecting more than 85% of carriers. How a partial loss of GATA2 functionality… read more here.
Keywords: cellular metabolic; metabolic characteristics; gata2; pre leukemic ... See more keywords