Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis
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DOI: 10.1038/s42003-022-03009-4
Abstract: Early diagnosis of acute myeloid leukemia (AML) in the pre-leukemic stage remains a clinical challenge, as pre-leukemic patients show no symptoms, lacking any known morphological or numerical abnormalities in blood cells. Here, we demonstrate that… read more here.
Keywords: myeloid leukemia; platelets pre; acute myeloid; pre leukemic ... See more keywords
Prodromal / Pre-Leukemic Acute Leukemia of B-Lymphoblasts in 7 Adult Patients
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DOI: 10.1182/blood-2020-143455
Abstract: Background: Prodromal/pre-leukemic acute leukemia is rare, mostly described in childhood B-lymphoblastic leukemia (B-ALL), with its initial presentation confused with aplastic anemia (AA). Findings reported in pediatric prodromal/pre-leukemic B-ALL include female preponderance, bone marrow (BM) fibrosis… read more here.
Keywords: acute leukemia; prodromal pre; pre leukemic;
Persistent DNA damage and oncogenic stress-induced Trem1 promotes leukemia in mice
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DOI: 10.3324/haematol.2021.280404
Abstract: The immune receptor TREM1 (Triggering receptor expressed on myeloid cells 1) is a master regulator of inflammatory response. Compelling evidence suggests important pathological roles for TREM1 in various types of solid tumors. However, the role… read more here.
Keywords: hsc lsc; dna damage; pre leukemic; trem1 ... See more keywords
Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsuficiency.
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DOI: 10.3324/haematol.2022.279437
Abstract: Mono-Allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) affecting more than 85% of carriers. How a partial loss of GATA2 functionality… read more here.
Keywords: cellular metabolic; metabolic characteristics; gata2; pre leukemic ... See more keywords