Icaritin ameliorates extracellular microparticles‐induced inflammatory pre‐metastatic niche via modulating the cGAS‐STING signaling
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7433
Abstract: The concept of the inflammatory pre‐metastatic niche (PMN) provides a new and promising direction for the prevention and treatment of metastasis. The excessive activation of the GAS‐STING signaling leads to augmented metastasis by promoting the… read more here.
Keywords: pre metastatic; sting signaling; inflammatory pre; metastatic niche ... See more keywords
Dendritic cells development into osteoclast-type APCs by 4T1 breast tumor T cells milieu boost bone consumption.
Sign Up to like & getrecommendations! Published in 2020 at "Bone"
DOI: 10.1016/j.bone.2020.115755
Abstract: Bone metastases occur in 70% of patients with advanced breast cancer, causing severe morbidity and increased mortality due to osteolytic lesions driven by osteoclasts (OCs) inside the bone marrow (BM) microenvironment. A reciprocal vicious cycle… read more here.
Keywords: pre metastatic; tumor cells; bone; dendritic cells ... See more keywords
High throughput sequencing identifies breast cancer-secreted exosomal LncRNAs initiating pulmonary pre-metastatic niche formation.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.06.004
Abstract: OBJECTIVE Increasing evidence indicated that cancer-secreted exosomes played an important role in tumor metastasis. However, the function of exosomes in breast cancer pulmonary metastasis remains unknown. The aim of the study was to investigate the… read more here.
Keywords: pre metastatic; cancer secreted; niche formation; metastatic niche ... See more keywords
Bone-marrow-derived cell-released extracellular vesicle miR-92a regulates hepatic pre-metastatic niche in lung cancer
Sign Up to like & getrecommendations! Published in 2019 at "Oncogene"
DOI: 10.1038/s41388-019-1024-y
Abstract: Metastatic tumors have been shown to establish a supportive pre-metastatic niche (PMN) in distant organs, which in turn determines disseminated tumor cells’ targeting of such organs. PMN is formed through the recruitment of bone-marrow-derived cells… read more here.
Keywords: pre metastatic; lung cancer; cancer; cell ... See more keywords
A liposome-based combination strategy using doxorubicin and a PI3K inhibitor efficiently inhibits pre-metastatic initiation by acting on both tumor cells and tumor-associated macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d1nr08215a
Abstract: Pre-metastatic initiation is essential in tumor metastasis, and the inhibition of it could prevent the spread of cancers to distant organs. Both tumor-associated macrophages (TAMs) and the epithelial-mesenchymal transition (EMT) play an important role in… read more here.
Keywords: pre metastatic; tumor cells; combination; metastatic initiation ... See more keywords
Abstract 101: Human bone marrow-derived endothelial progenitor cells promote the transformation of periostin-positive hepatocellular carcinoma cells into CD36-positive metastasis-initialing cells in pre-metastatic niche
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-101
Abstract: BACKGROUND: Recent studies have shown that metastasis-initiating cells (MICs) in the pre-metastatic niche play a key role in triggering tumor metastasis. In addition, bone marrow-derived endothelial progenitor cells (BM-EPCs), which are key components of the… read more here.
Keywords: pre metastatic; transformation; metastasis; cd36 positive ... See more keywords
Abstract 1230: The pre-metastatic niche establishment through the induction of the epithelial-to-mesenchymal transition by circulating exosomes in lymphangioleiomyomatosis (LAM): implication of the complement cascade
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1230
Abstract: Exosomes are a class of extra cellular vesicles (EVs), with a multi vesicular endosomal origin, that are released by all cell types, with sizes ranging from 30-150nm and a lipid bilayer membrane. They have been… read more here.
Keywords: lymphangioleiomyomatosis lam; derived exosomes; pre metastatic; niche establishment ... See more keywords
Abstract P6-01-18: Early detection of development of a pre-metastatic niche in lungs in response to primary breast tumor using Raman spectroscopy
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs16-p6-01-18
Abstract: Background: An alarmingly large proportion of cancer-related deaths result from metastatic cancers. Development of quick, reliable and non-invasive or minimally invasive approaches to objectively assess the secondary tissues (potentially in vivo) will be instrumental in… read more here.
Keywords: pre metastatic; metastatic niche; spectroscopy; cancer ... See more keywords
Abstract PO051: Fibroblast lineage tracing in metastatic and pre-metastatic microenvironments
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.tme21-po051
Abstract: Metastatic breast cancer is one of the leading causes of cancer-related mortality among women. However, the complex process of tumor cell dissemination and colonization of distant tissues is incompletely understood and largely incurable using existing… read more here.
Keywords: pre metastatic; cancer; tumor; collagen ... See more keywords
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation
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DOI: 10.18632/oncotarget.18831
Abstract: Exosomes play important roles in cell-cell communication, and are likely mediators of the metastatic cascade in cancer. This study examined the role of exosomes in pancreatic cancer cell adhesion, migration, and invasion. We isolated and… read more here.
Keywords: pre metastatic; metastatic niche; pancreatic cancer; metastasis ... See more keywords
Exosomal tetraspanins mediate cancer metastasis by altering host microenvironment
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.19119
Abstract: The metastases of malignant tumors develop through a cascade of events. The establishment of a pre-metastatic micro-environment is initiated by communication between tumors and host. Exosomes come into focus as the most potent intercellular communicators… read more here.
Keywords: tetraspanin; pre metastatic; exosomal tetraspanin; cancer metastasis ... See more keywords