Bioengineering of a single long noncoding RNA molecule that carries multiple small RNAs
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09934-5
Abstract: Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), small interfering RNAs (siRNAs), and long noncoding RNAs (lncRNAs), regulate target gene expression and can be used as tools for understanding biological processes and identifying new therapeutic targets. Currently,… read more here.
Keywords: long noncoding; pre mir; mir 34a; multiple small ... See more keywords
The Natural Product Butylcycloheptyl Prodiginine Binds Pre-miR-21, Inhibits Dicer-Mediated Processing of Pre-miR-21, and Blocks Cellular Proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2019.04.011
Abstract: Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Using a high-throughput differential scanning fluorimetry assay, we identified small-molecule natural products with the capacity to bind the discrete stem-looped… read more here.
Keywords: butylcycloheptyl prodiginine; dicer mediated; pre mir; mir ... See more keywords
Regulation of SPOCK1 by dual strands of pre-miR-150 inhibit cancer cell migration and invasion in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Human Genetics"
DOI: 10.1038/jhg.2017.69
Abstract: Analysis of our microRNA (miRNA) expression signatures of human cancers based on RNA sequencing have shown that both strands of pre-miR-150, miR-150-5p (the guide strand) and miR-150-3p (the passenger strand), are significantly reduced in cancer… read more here.
Keywords: pre mir; mir 150; cancer cell; cell ... See more keywords
Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Extracellular Vesicles"
DOI: 10.1080/20013078.2017.1333882
Abstract: ABSTRACT Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce… read more here.
Keywords: extracellular vesicles; tar; pre mir; mir 199a ... See more keywords
A Rare Rs139365823 Polymorphism in Pre-miR-138 Is Associated with Risk of Congenital Heart Disease in a Chinese Population.
Sign Up to like & getrecommendations! Published in 2018 at "DNA and cell biology"
DOI: 10.1089/dna.2017.4013
Abstract: miR-138 modulates cardiac morphogenesis in zebrafish. We explored whether a genetic polymorphism in miR-138 might contribute to the occurrence of sporadic congenital heart disease (CHD) and the potential mechanism. We performed a case-control study consisting… read more here.
Keywords: risk; rs139365823; pre mir; mir 138 ... See more keywords
Association of selected polymorphisms in GPX4, COMT, pre-miR-125a, pre-miR-10a, and pre-miR-323b genes in Iranian women with idiopathic recurrent pregnancy loss: A case-control study
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Reproductive Biomedicine"
DOI: 10.18502/ijrm.v20i2.10503
Abstract: Abstract Background Recurrent pregnancy loss (RPL) is a major concern among women worldwide. However, the exact mechanisms underlying miscarriage are not well understood. Recent evidence suggests that single nucleotide polymorphisms in various genes, especially miRNAs,… read more here.
Keywords: pre; mir 10a; pre mir; 125a pre ... See more keywords
The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
Sign Up to like & getrecommendations! Published in 2022 at "General physiology and biophysics"
DOI: 10.4149/gpb_2022033
Abstract: Study was focused on regulatory interactions between the circadian system and the renin-angiotensin system in control of microRNA (miRNA) biosynthesis. Responsiveness of the miRNA biosynthetic pathway, selected pre-miRNAs and clock genes to angiotensin II (AngII)… read more here.
Keywords: peripheral tissues; angiotensin; pre mir; expression ... See more keywords