Functional MoS2 nanosheets for precursor and mature microRNA detection in living cells
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-01753-x
Abstract: AbstractMature microRNAs (miRNAs) are small-sized RNAs cleaved from precursor microRNAs (pre-miRNAs) by the RNase Dicer. Various miRNAs play key regulatory roles in tumorigenesis and metastasis, and are therefore potential diagnostic and prognostic cancer biomarkers. However,… read more here.
Keywords: mirna pre; functional mos2; mos2 nanosheets; pre mirna ... See more keywords
Genome wide identification, characterization and validation of novel miRNA-based SSR markers in pomegranate (Punica granatum L.)
Sign Up to like & getrecommendations! Published in 2020 at "Physiology and Molecular Biology of Plants"
DOI: 10.1007/s12298-020-00790-6
Abstract: A total of 17,439 mature miRNAs (~ 21 nt) earlier generated through RNA seq in the pomegranate were used for in silico analysis. After complexity reduction, a total of 1922 representative mature miRNAs were selected and… read more here.
Keywords: mirna; mirna ssrs; pre; pri ... See more keywords
Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.03.080
Abstract: Human Dicer (hDicer) is a multi-domain protein belonging to the RNase III family. It plays pivotal roles in small RNA biogenesis during the RNA interference (RNAi) pathway by processing a diverse range of double-stranded RNA (dsRNA)… read more here.
Keywords: human dicer; pre mirna; cryo structure; hdicer ... See more keywords
Three-in-One System Based on Multi-Path Nucleic Acid Amplification for Bioanalysis of Pre-miRNA/miRNA and Dicer Activity.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00432
Abstract: Today, a lot of attention is being paid to the pre-miRNAs/miRNAs or activity of Dicer due to their important functions in various physiological processes. Especially, the intrinsic relationship among these associated targets is of significant… read more here.
Keywords: bioanalysis; pre mirna; acid amplification; multi path ... See more keywords
Discrimination between Cancer Cells and DNA-Damaged Cells: Pre-miRNA Region Recognition Based on Hyperbranched Hybrid Chain Reaction Amplification for Simultaneous Sensitive Detection and Imaging of miRNA and Pre-miRNA.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c01918
Abstract: Herein, a novel region recognition of precursor microRNA (Pre-miRNA) based on hyperbranched hybrid chain reaction (HB-HCR) amplification was constructed to effectively eliminate the interference of Pre-miRNA to the mature microRNA (miRNA) by establishing the linear… read more here.
Keywords: detection; mirna pre; pre mirna; pre ... See more keywords
A hybrid CNN-LSTM model for pre-miRNA classification
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93656-0
Abstract: miRNAs (or microRNAs) are small, endogenous, and noncoding RNAs construct of about 22 nucleotides. Cumulative evidence from biological experiments shows that miRNAs play a fundamental and important role in various biological processes. Therefore, the classification… read more here.
Keywords: cnn lstm; classification; pre mirna; mirna classification ... See more keywords
miWords: transformer-based composite deep learning for highly accurate discovery of pre-miRNA regions across plant genomes
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbad088
Abstract: Discovering pre-microRNAs (miRNAs) is the core of miRNA discovery. Using traditional sequence/structural features, many tools have been published to discover miRNAs. However, in practical applications like genomic annotations, their actual performance has been very low.… read more here.
Keywords: mirna; composite deep; pre mirna; discovery ... See more keywords
ReCGBM: a gradient boosting-based method for predicting human dicer cleavage sites
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-03993-0
Abstract: Background Human dicer is an enzyme that cleaves pre-miRNAs into miRNAs. Several models have been developed to predict human dicer cleavage sites, including PHDCleav and LBSizeCleav. Given an input sequence, these models can predict whether… read more here.
Keywords: dicer cleavage; dicer; pre mirna; cleavage sites ... See more keywords
Characterization of a G-Quadruplex Structure in Pre-miRNA-1229 and in Its Alzheimer’s Disease-Associated Variant rs2291418: Implications for miRNA-1229 Maturation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21030767
Abstract: Alzheimer’s disease (AD), the most common age-related neurodegenerative disease, is associated with various forms of cognitive and functional impairment that worsen with disease progression. AD is typically characterized as a protein misfolding disease, in which… read more here.
Keywords: mirna; disease; pre mirna; structure ... See more keywords
Pre-miRNA Hsa-Let-7a-2: a Novel Intracellular Partner of Angiotensin II Type 2 Receptor Negatively Regulating its Signals
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70455
Abstract: G protein-coupled receptors (GPCRs) are the largest family of druggable targets, and their biological functions depend on different ligands and intracellular interactomes. Some microRNAs (miRNAs) bind as ligands to RNA-sensitive toll-like receptor 7 to regulate… read more here.
Keywords: hsa let; let; type receptor; pre mirna ... See more keywords