Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values
Sign Up to like & getrecommendations! Published in 2025 at "Genes"
DOI: 10.1002/gcc.70027
Abstract: Breast cancer, a molecularly heterogeneous disease, is classified into hormone receptor‐positive luminal breast cancer (LBC), human epidermal growth factor receptor 2‐positive breast cancer, and triple‐negative breast cancer (TNBC). Precursor microRNAs (pre‐miRNAs), typically form hairpin structures… read more here.
Keywords: total rna; pre mirnas; cancer; breast cancer ... See more keywords
pH dependence of C•A, G•A and A•A mismatches in the stem of precursor microRNA-31.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2022.106763
Abstract: MicroRNAs (miRNAs) are important regulators of post-transcriptional gene expression. Mature miRNAs are generated from longer transcripts (primary, pri- and precursor, pre-miRNAs) through a series of highly coordinated enzymatic processing steps. The sequence and structure of… read more here.
Keywords: mismatches stem; pre; dependence mismatches; base pair ... See more keywords
Genome-wide discovery of pre-miRNAs: comparison of recent approaches based on machine learning
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa184
Abstract: MOTIVATION The genome-wide discovery of microRNAs (miRNAs) involves identifying sequences having the highest chance of being a novel miRNA precursor (pre-miRNA), within all the possible sequences in a complete genome. The known pre-miRNAs are usually… read more here.
Keywords: pre mirnas; genome wide; machine learning; wide discovery ... See more keywords
Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab215
Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) expresses miRNAs during latency. However, regulation of viral miRNAs remains largely unknown. Our prior studies demonstrated that MCPIP1 regulates KSHV miRNA biogenesis by degrading most KSHV pre-miRNAs through its RNase activity.… read more here.
Keywords: pre mirnas; kshv infection; viral mirnas; infection ... See more keywords
Deep neural networks for human microRNA precursor detection
Sign Up to like & getrecommendations! Published in 2020 at "BMC Bioinformatics"
DOI: 10.1186/s12859-020-3339-7
Abstract: Background MicroRNAs (miRNAs) play important roles in a variety of biological processes by regulating gene expression at the post-transcriptional level. So, the discovery of new miRNAs has become a popular task in biological research. Since… read more here.
Keywords: pre mirnas; deep neural; neural networks; dataset ... See more keywords
A deeper view into the significance of simple sequence repeats in pre-miRNAs provides clues for its possible roles in determining the function of microRNAs
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genetics"
DOI: 10.1186/s12863-018-0615-x
Abstract: BackgroundThe central tenet of ‘genome content’ has been that the ‘non-coding’ parts are highly enriched with ‘microsatellites’ or ‘Simple Sequence Repeats’ (SSRs). We presume that the presence and change in number of repeat unit (n)… read more here.
Keywords: pre mirnas; ssrs; simple sequence; function ... See more keywords
Intramolecular ligation method (iLIME) for pre-miRNA quantification and sequencing
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079101.122
Abstract: Hairpin-containing pre-miRNAs, produced from pri-miRNAs, are precursors of miRNAs (microRNAs) that play essential roles in gene expression and various human diseases. Current qPCR-based methods used to quantify pre-miRNAs are not effective to discriminate between pre-miRNAs… read more here.
Keywords: pre mirnas; ligation method; intramolecular ligation; pre ... See more keywords