pH dependence of C•A, G•A and A•A mismatches in the stem of precursor microRNA-31.
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2022.106763
Abstract: MicroRNAs (miRNAs) are important regulators of post-transcriptional gene expression. Mature miRNAs are generated from longer transcripts (primary, pri- and precursor, pre-miRNAs) through a series of highly coordinated enzymatic processing steps. The sequence and structure of… read more here.
Keywords: mismatches stem; pre; dependence mismatches; base pair ... See more keywords
Genome-wide discovery of pre-miRNAs: comparison of recent approaches based on machine learning
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa184
Abstract: MOTIVATION The genome-wide discovery of microRNAs (miRNAs) involves identifying sequences having the highest chance of being a novel miRNA precursor (pre-miRNA), within all the possible sequences in a complete genome. The known pre-miRNAs are usually… read more here.
Keywords: pre mirnas; genome wide; machine learning; wide discovery ... See more keywords
Monocyte chemoattractant protein-induced protein 1 directly degrades viral miRNAs with a specific motif and inhibits KSHV infection.
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic acids research"
DOI: 10.1093/nar/gkab215
Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) expresses miRNAs during latency. However, regulation of viral miRNAs remains largely unknown. Our prior studies demonstrated that MCPIP1 regulates KSHV miRNA biogenesis by degrading most KSHV pre-miRNAs through its RNase activity.… read more here.
Keywords: pre mirnas; kshv infection; viral mirnas; infection ... See more keywords
Deep neural networks for human microRNA precursor detection
Sign Up to like & getrecommendations! Published in 2020 at "BMC Bioinformatics"
DOI: 10.1186/s12859-020-3339-7
Abstract: Background MicroRNAs (miRNAs) play important roles in a variety of biological processes by regulating gene expression at the post-transcriptional level. So, the discovery of new miRNAs has become a popular task in biological research. Since… read more here.
Keywords: pre mirnas; deep neural; neural networks; dataset ... See more keywords
A deeper view into the significance of simple sequence repeats in pre-miRNAs provides clues for its possible roles in determining the function of microRNAs
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genetics"
DOI: 10.1186/s12863-018-0615-x
Abstract: BackgroundThe central tenet of ‘genome content’ has been that the ‘non-coding’ parts are highly enriched with ‘microsatellites’ or ‘Simple Sequence Repeats’ (SSRs). We presume that the presence and change in number of repeat unit (n)… read more here.
Keywords: pre mirnas; ssrs; simple sequence; function ... See more keywords
Intramolecular ligation method (iLIME) for pre-miRNA quantification and sequencing
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079101.122
Abstract: Hairpin-containing pre-miRNAs, produced from pri-miRNAs, are precursors of miRNAs (microRNAs) that play essential roles in gene expression and various human diseases. Current qPCR-based methods used to quantify pre-miRNAs are not effective to discriminate between pre-miRNAs… read more here.
Keywords: pre mirnas; ligation method; intramolecular ligation; pre ... See more keywords