Structure-Guided Designing Pre-Organization in Bivalent Aptamers.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12593
Abstract: Multivalent interaction is often used in molecular design and leads to engineered multivalent ligands with increased binding avidities toward target molecules. The resulting binding avidity relies critically on the rigid scaffold that joins multiple ligands… read more here.
Keywords: design; structure guided; bivalent; pre organization ... See more keywords
Road-blocker HSP disease mutation disrupts pre-organization for ATP hydrolysis in kinesin through a second sphere control
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215170120
Abstract: Significance Kinesin, an amazing biological machine, converts chemical energy from the ATP hydrolysis into mechanical energy to perform different cellular activities. Several single-point gene-level mutations in the neuronal kinesin motor (KIF5A) are linked to a… read more here.
Keywords: pre organization; kinesin second; second sphere; atp hydrolysis ... See more keywords