Marked elevation of serum lactate dehydrogenase in primary myelofibrosis: clinical and prognostic correlates
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DOI: 10.1038/s41408-017-0024-9
Abstract: Primary myelofibrosis (PMF) is a clonal stem cell-derived myeloproliferative neoplasm (MPN), characterized by dysregulated proliferation of megakaryocytes, myeloid and erythroid cells, extramedullary hematopoiesis, and reactive changes in the bone marrow, including reticulin deposition, osteosclerosis, and… read more here.
Keywords: primary myelofibrosis; pmf; pre pmf; serum ... See more keywords
Prefibrotic myelofibrosis: treatment algorithm 2018
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DOI: 10.1038/s41408-018-0142-z
Abstract: Prefibrotic myelofibrosis (pre-PMF) is a distinct entity among chronic myeloproliferative neoplasm diagnosed according to the revised 2016 WHO classification. The clinical picture is heterogeneous, ranging from isolated thrombocytosis, mimicking essential thrombocythemia (ET), to symptoms of… read more here.
Keywords: risk; prefibrotic myelofibrosis; treatment; myelofibrosis treatment ... See more keywords
Clinical and molecular features of patients with prefibrotic primary myelofibrosis previously diagnosed as having essential thrombocythemia in Japan
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DOI: 10.1111/ejh.13236
Abstract: Prefibrotic/early primary myelofibrosis (pre‐PMF) and essential thrombocythemia (ET) exhibited different features of bone marrow; however, this is not always easy to judge objectively, making pathologists’ distinction often suboptimal. In the WHO 2008 criteria, pre‐PMF was… read more here.
Keywords: primary myelofibrosis; previously diagnosed; essential thrombocythemia; pre pmf ... See more keywords
A Predictive Model for Progression to Overt Primary Myelofibrosis in Early/Prefibrotic Primary Myelofibrosis Patients
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DOI: 10.1182/blood-2024-204773
Abstract: Introduction:The 2016 WHO reclassified myelofibrosis into two distinct entities: early/prefibrotic primary myelofibrosis (pre-PMF) and overt primary myelofibrosis (overt-PMF). Approximately 15% of pre-PMF patients progress to overt-PMF during the disease course. Currently, there is limited research… read more here.
Keywords: primary myelofibrosis; pmf; overt pmf; risk ... See more keywords
Treatment landscape and outcome of myeloproliferative neoplasms in asia: Interim analysis of the Asian myeloproliferative neoplasm registry
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DOI: 10.1182/blood-2025-2041
Abstract: Background Large multicenter analysis of myeloproliferative neoplasms (MPNs) has not been conducted in Asia. Aims This project aims to define the clinicopathologic characteristics, treatment landscape and outcome of MPNs in Asia. Methods This is a… read more here.
Keywords: pmf; analysis; pre pmf; mpn ... See more keywords
Unraveling progression predictors in prefibrotic myelofibrosis: A 2,000-patient systematic review and meta-analysis
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DOI: 10.1182/blood-2025-7271
Abstract: Background: Prefibrotic primary myelofibrosis (pre-PMF) is a distinct clinical entity within the myeloproliferative neoplasms (MPNs), often underrecognized despite its potential progression to overt myelofibrosis (MF) or acute myeloid leukemia (AML). The heterogeneity in clinical outcomes… read more here.
Keywords: myelofibrosis; progression; analysis; risk ... See more keywords
Splenic Infarction in Patients with Philadelphia-negative Myeloproliferative Neoplasms
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DOI: 10.2169/internalmedicine.9124-21
Abstract: Objective We retrospectively analyzed the prevalence and clinical features of splenic infarctions in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (Ph- MPNs). Patients Patients diagnosed with essential thrombocythemia (ET), polycythemia vera (PV), prefibrotic/early primary myelofibrosis (pre-PMF),… read more here.
Keywords: pmf; patients philadelphia; pre pmf; splenic infarctions ... See more keywords