Target-binding behavior of IDPs via pre-structured motifs.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2021.07.031
Abstract: Pre-Structured Motifs (PreSMos) are transient secondary structures observed in many intrinsically disordered proteins (IDPs) and serve as protein target-binding hot spots. The prefix "pre" highlights that PreSMos exist a priori in the target-unbound state of… read more here.
Keywords: pre structured; target; idps; target binding ... See more keywords
Rescuing p53 from mdm2 by a pre-structured motif in intrinsically unfolded SUMO specific protease 4
Sign Up to like & getrecommendations! Published in 2017 at "BMB Reports"
DOI: 10.5483/bmbrep.2017.50.10.131
Abstract: Many intrinsically unstructured/unfolded proteins (IUPs) contain transient local secondary structures even though they are “unstructured” in a tertiary sense. These local secondary structures are named “pre-structured motifs (PreSMos)” and in fact are the specificity determinants… read more here.
Keywords: pre structured; specific protease; p53; p53 mdm2 ... See more keywords