In vivo evidence for pre‐symptomatic neuroinflammation in a MAPT mutation carrier
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.683
Abstract: Neuroinflammation occurs in frontotemporal dementia, however its timing relative to protein aggregation and neuronal loss is unknown. Using positron emission tomography and magnetic resonance imaging to quantify these processes in a pre‐symptomatic carrier of the… read more here.
Keywords: neuroinflammation; carrier; pre symptomatic; mapt mutation ... See more keywords
Is Pre‐Symptomatic Immunosuppression Protective in CSF1R‐Related Leukoencephalopathy?
Sign Up to like & getrecommendations! Published in 2021 at "Movement Disorders"
DOI: 10.1002/mds.28515
Abstract: Adult-onset leukoencephalopathy with spheroids and pigmented glia (ALSP) is the collective disease referring to patients previously diagnosed with hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS) or pigmented orthochromatic leukodystrophy (POLD). ALSP is a white matter… read more here.
Keywords: csf1r; pre symptomatic; disease; related leukoencephalopathy ... See more keywords
The role of asymptomatic and pre-symptomatic infection in SARS-CoV-2 transmission—a living systematic review
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Microbiology and Infection"
DOI: 10.1016/j.cmi.2021.01.011
Abstract: Background Reports suggest that asymptomatic individuals (those with no symptoms at all throughout infection) with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are infectious, but the extent of transmission based on symptom status requires further… read more here.
Keywords: index; transmission; infection; pre symptomatic ... See more keywords
Choosing not to know: accounts of non-engagement with pre-symptomatic testing for Machado-Joseph disease
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-018-0308-y
Abstract: This paper reports accounts from people at-risk for, or affected by, Machado-Joseph disease, and their family members, about their decisions not to seek pre-symptomatic testing, therefore remaining (for the time) uninformed about their genetic status.… read more here.
Keywords: machado joseph; pre symptomatic; non engagement; family ... See more keywords
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases
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DOI: 10.1093/brain/awab404
Abstract: Abstract Significant progress has been made in understanding the pre-symptomatic phase of amyotrophic lateral sclerosis. While much is still unknown, advances in other neurodegenerative diseases offer valuable insights. Indeed, it is increasingly clear that the… read more here.
Keywords: lateral sclerosis; pre symptomatic; disease; amyotrophic lateral ... See more keywords
Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa422
Abstract: Abstract How genetic defects trigger the molecular changes that cause late-onset disease is important for understanding disease progression and therapeutic development. Fuchs’ endothelial corneal dystrophy (FECD) is an RNA-mediated disease caused by a trinucleotide CTG… read more here.
Keywords: late onset; rna; pre symptomatic; disease ... See more keywords
Pre‐symptomatic transmission of novel coronavirus in community settings
Sign Up to like & getrecommendations! Published in 2020 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12773
Abstract: We used contact tracing to document how COVID‐19 was transmitted across 5 generations involving 10 cases, starting with an individual who became ill on January 27. We calculated the incubation period of the cases as… read more here.
Keywords: coronavirus community; novel coronavirus; pre symptomatic; community settings ... See more keywords
Evidence for pre‐symptomatic transmission of coronavirus disease 2019 (COVID‐19) in China
Sign Up to like & getrecommendations! Published in 2020 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.12787
Abstract: Between mid‐January and early February, provinces of mainland China outside the epicentre in Hubei province were on high alert for importations and transmission of COVID‐19. Many properties of COVID‐19 infection and transmission were still not… read more here.
Keywords: transmission; pre symptomatic; transmission coronavirus; coronavirus disease ... See more keywords
Asymptomatic COVID-19 in the elderly: dementia and viral clearance as risk factors for disease progression.
Sign Up to like & getrecommendations! Published in 2022 at "Gates Open Research"
DOI: 10.12688/gatesopenres.13357.2
Abstract: Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per country. Among those… read more here.
Keywords: progression; covid; cov infected; dementia ... See more keywords
Low rate of SARS-CoV-2 incident infection identified by weekly screening PCR in a prospective year-long cohort study
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0274078
Abstract: Background Asymptomatic and pre-symptomatic SARS-CoV-2 infections may contribute to ongoing community transmission, however, the benefit of routine screening of asymptomatic individuals in low-risk populations is unclear. Methods To identify SARS-CoV-2 infections 553 seronegative individuals were… read more here.
Keywords: sars2 cov; cov infections; infection; pre symptomatic ... See more keywords
Estimating the generation interval for coronavirus disease (COVID-19) based on symptom onset data, March 2020
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DOI: 10.2807/1560-7917.es.2020.25.17.2000257
Abstract: Background Estimating key infectious disease parameters from the coronavirus disease (COVID-19) outbreak is essential for modelling studies and guiding intervention strategies. Aim We estimate the generation interval, serial interval, proportion of pre-symptomatic transmission and effective… read more here.
Keywords: generation; pre symptomatic; disease; generation interval ... See more keywords