A four-drug standardized short regimen for highly resistant TB in South-West Nigeria.
Sign Up to like & getrecommendations! Published in 2023 at "International health"
DOI: 10.1093/inthealth/ihad023
Abstract: BACKGROUND Patients with TB resistant to rifampicin (Rr-TB), and those with additional resistance to fluoroquinolones (pre-XDR-TB), should be treated with bedaquiline-pretomanid-linezolid-moxifloxacin and bedaquiline-pretomanid-linezolid, respectively. However, pretomanid is not yet widely available. METHODS This is a… read more here.
Keywords: drug standardized; bedaquiline; pre xdr; highly resistant ... See more keywords
The Relevance of Host Gut Microbiome Signature Alterations on de novo Fatty Acids Synthesis in Patients with Multi-Drug Resistant Tuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s372122
Abstract: Background Tuberculosis (TB) is still the single pathogen infectious disease with the largest number of deaths worldwide. The relationship that intestinal microbiota disorder and de novo fatty acid synthesis metabolism have with disease progression in… read more here.
Keywords: gut microbiome; synthesis; novo fatty; pre xdr ... See more keywords
Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1069292
Abstract: Background Resistance to tuberculosis (TB) drugs has become a major threat to global control efforts. Early case detection and drug susceptibility profiling of the infecting bacteria are essential for appropriate case management. The objective of… read more here.
Keywords: difficult treat; mdr; pre xdr; resistance ... See more keywords
Cross-Contamination versus Outbreak: Pre-XDR Mycobacterial Strains Confirmed by Whole-Genome Sequencing
Sign Up to like & getrecommendations! Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10030297
Abstract: Whole-genome sequencing (WGS) is promising for the quality control of laboratory facilities for Mycobacterium tuberculosis (MTB) strains. We describe the clinical and laboratory characteristics of false positive versus true positive MTB cultures based on WGS,… read more here.
Keywords: cross contamination; genome sequencing; pre xdr; whole genome ... See more keywords
Yield of Systematic Longitudinal Screening of Household Contacts of Pre-Extensively Drug Resistant (PreXDR) and Extensively Drug Resistant (XDR) Tuberculosis Patients in Mumbai, India
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Medicine and Infectious Disease"
DOI: 10.3390/tropicalmed5020083
Abstract: While risk of tuberculosis (TB) is high among household contacts (HHCs) of pre-extensively drug resistant (pre-XDR) TB and XDR-TB, data on yield of systematic longitudinal screening are lacking. We aim to describe the yield of… read more here.
Keywords: drug; extensively drug; drug resistant; yield ... See more keywords