Selective Synthesis of Lysine Peptides and the Prebiotically Plausible Synthesis of Catalytically Active Diaminopropionic Acid Peptide Nitriles in Water
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DOI: 10.1021/jacs.2c12497
Abstract: Why life encodes specific proteinogenic amino acids remains an unsolved problem, but a non-enzymatic synthesis that recapitulates biology’s universal strategy of stepwise N-to-C terminal peptide growth may hold the key to this selection. Lysine is… read more here.
Keywords: water; synthesis; lysine; prebiotically plausible ... See more keywords
In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1914367117
Abstract: Significance Current models for the origin of life include an earlier period when prebiotic chemistry dictated the nonenzymatic copying of RNA polymers, followed by a period of ribozyme-catalyzed reactions using nucleoside-5′-triphosphate (NTP) substrates. Our study… read more here.
Keywords: ribozyme; template; rna; rna substrates ... See more keywords