Precipitate-Supported Thermal Proteome Profiling Coupled with Deep Learning for Comprehensive Screening of Drug Target Proteins.
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DOI: 10.1021/acschembio.1c00936
Abstract: Although thermal proteome profiling (TPP) acts as a popular modification-free approach for drug target deconvolution, some key problems are still limiting screening sensitivity. In the prevailing TPP workflow, only the soluble fractions are analyzed after… read more here.
Keywords: drug target; thermal proteome; drug; precipitate supported ... See more keywords